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Basic strategies in the design of antiviral drugs have been described previously.1 Here, I evaluate antiviral drug targets and strategies that would be of primary importance in the case of an advertent or inadvertent virus outbreak or attack. In particular, I focus on the virus infections reviewed in Table 4.1. Of the viral agents listed in Table 4.1, poxviruses such as variola (smallpox), arenaviruses such as Lassa, and loviruses such as Ebola and Marburg belong to Category A or highest priority agents [according to Centers for Disease Control and Prevention (CDC)] because they can easily be disseminated or transmitted from person to person, result in high mortality rates and have the potential for major public health impact, may cause public panic and social disruption, and require special action for public health preparedness. The alphaviruses western, eastern, and Venezuelan equine encephalitis belong to Category B. 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