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Current services have a strong historical and socio-political legacy. Understanding the development of services requires an appreciation of these factors. Medieval historians debate the rst documentation of women suffering with illnesses which appear to t modern day criteria for anorexia nervosa and discuss early aetiological theories. It was in 1873 that the physician Sir William Gull nally named the disorder while working at Guy s Hospital, London (Gull, 1873). Although psychosocial factors were recognised in the aetiology of the condition it was general physicians who took the lead in the management of anorexia nervosa during the nineteenth century and the rst half of the twentieth (see Figure 20.1). During the latter part of the twentieth century we saw a gradual shift in the management of anorexia nervosa from physicians to psychiatrists in most European countries,



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The networked web of people and ideas online suggests some metaphors more than others, but the ones that work for you of course depend upon you. Table 8-1 gives some example situations and applicable metaphors to give you an idea of how multiple metaphor career management might work.

25 Therefore, with a notional contract value of $1 million, 1 basis point change translates into $25 Figure 58 showed scenarios that might create a slight slope in the duration line of the forward as it approached the duration of the underlying spot asset; this slope represents carry s contribution to duration In short, as purely convenience for itself and its investors, the futures exchanges price the sensitivity of the underlying spot values of the Treasury bills and Eurodollars at their spot duration value (three months) This con-.





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:rule r14 rule (goal Miss will get eaten on right, backtrack) IF ( in Max boat <MX>) ( in Boat state = "R" AND total = <MX>) ( in Right cann = <RC> AND miss < <RC> AND miss > 0) THEN warning rule r14 - miss will get eaten on right on shore\, backtracking\n , delete 2 , delete 3 ; :rule r15 rule (goal Miss will get eaten on right in boat, backtrack) IF ( in Max boat <MX>) ( in Boat state = "R" AND cann = <BC> AND miss < <BC> AND total = <MX>) ( in Right miss = <RM>) THEN warning rule r15 - miss will get eaten on right in boat\, backtracking\n , delete 2 , delete 3 ; : ----------------------------------------------------- : UNLOAD ON LEFT BANK :rule r16 rule (goal Check new left bank totals to see if unloading is possible) IF ( in Boat state = "RL" miss = <BM> AND cann = <BC> AND total = <BT>) ( in Left miss = <LM> AND cann = <LC> AND total = <LT>) THEN write rule r16 - checking new bank totals on left\n , make Temp miss = (<BM> + <LM>) cann = (<BC> + <LC>) total = (<BT> + <LT>) ; :rule r17 rule (goal OK, unload on left bank) IF ( in Temp miss = <TM> AND cann = <TC> AND cann <= <TM> AND total = <TT>) ( in Boat state = "RL") ( in Left miss = <LM> AND cann = <LC> AND total = <LT>) THEN

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lead to mismatches of bases during DNA replication Genotoxic-induced damage, on the other hand, arises from direct interactions between environmental agents and DNA, either in their original form (direct acting genotoxins), or after biotransformation to a reactive intermediate (indirect acting genotoxins) Additionally, there are epigenetic processes, where DNA damage arises through such mechanisms as disruption of cellular macromolecules essential for the production and replication of new DNA Although many mutations are rare and detrimental, under certain conditions mutants may increase in frequency, and through selective mortality may lead to the evolution of adaptation Theoretical models suggest that natural selection will adjust mutation rates to intermediate levels, resulting in a balance between levels that minimise mortality and reduced tness (mutational load), while maximising genotypic variability to promote population persistence in changing environments (Gillespie, 1981).

Figure 2.9 Approximation scales for feature. Total depending on the categories CI, C II, and CIII (from left to right). (From [3].)

in terms of geodetic latitude fgeodetic , longitude y, and orthometric altitude h with respect to the reference geoid.

In natural environments, however, numerous agents interact to disrupt the mutation-selection balance through the process of mutagenesis, leading to impaired performance and reduced tness (Turelli, 1984, 1986) In natural populations, however, it is often dif cult to determine the intensity of selection and mutation rates for quantitative characters Mutation-selection balance can only maintain substantial genetic variation if a trait is affected by a large number of loci or if the mutation rate for loci in uencing a trait is high It is unclear how many loci affect stress resistance traits, though it has been shown in some cases to be determined by polymorphisms at a single gene, gene complex, or by multiple copies of a single gene (Depledge, 1994) It is essential that further studies are conducted to locate genes related to resistance traits, as well as documenting mutation rates in identi able genes under conditions of stress.

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