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Good control of SAR means that a chemist can make a small olecular change with resultant large change in the measured property Poor control of SAR means a loss of relationship between molecular structure and the measured property I believe it is inadvisable to totally lter out compounds with poor properties if they can easily be xed by chemistry The goal in drug research is to discover inherently active compounds with appropriate properties There is little value to being so restrictive that few inherently active compounds will be found Chemistry SAR for Solubility is Poor Chemistry control of aqueous solubility is poor The good news is that if a compound has poor aqueous solubility, methods do exist to x the problem Using Barcode generation for NET Control to generate create bar code image in NET applications. for c# to connect universal product code version a and universal product code version a data, size, image with visual c# barcode sdk. .( a) Encode the data D0 D1 D2 D3 D4 D5 1 0 1 1 0 1 0 0 1 1 0 1 . 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CHAPTER. scanning gtin - 12 on .net Using Barcode Control SDK for Visual Studio .NET .Related: C# Interleaved 2 of 5 Generating , Print Code 128 Word , ITF-14 Generating Word It takes no effort at all to introduce poor aqueous solubility to a combinatorial compound library he combination of high molecular weight and high lipophilicity outside the rule of ve limits15 is an almost certain guarantee of poor aqueous solubility Based on our experimental screening, lipophilicity above the rule of ve log P limit of 5 by itself carries with it a 75% chance of poor aqueous solubility Industry Solubility Changes The de nition of poor solubility has come downward in the combichem/HTS era A classic pharmaceutical science textbook might have de ned poor solubility as anything below a solubility of 1 g/mL at pH 65 (or pH 7) In today s era most drug researchers would be very excited by a solubility as high as 1 g/mL. 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