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Other mechanisms have been found that permit the expansion of the bacterial host range of phage based on the use of more than one bacterial receptor One such mechanism is site-speci c recombination systems that permit phage to switch between alternative tail ber proteins Recombination sites for DNA invertases and recombination sitelike sequences have been observed to ank gene segments conferring the speci city of a given phage for its host receptors When combined with the properties of DNA inversion, it is possible that the site-speci c recombination enzymes could be responsible for the exchange of host range determinants Sandmeier (1994) extensively reviewed the scienti c literature in this area, providing insight into the putative role of DNA inversion enzymes in the recombination of tail ber gene segments between genomes.



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The unique association of a mesh entity of dimension di , Midi , to the geometric model entity of dimension dj , Gj j , where di dj , on which it lies is termed as geometric classi cation and is denoted Midi Gj j , where the classi cation symbol, , indicates that the left-hand entity, or a set of entities, is classi ed on the right-hand entity Adjacencies describe how mesh entities connect to each other For an entity of dimension d, adjacency, denoted by {Mid {M q }}, returns all the mesh entities of dimension q, which are on the closure of the entity for a downward adjacency (d > q), or for which the entity is part of the closure for an upward adjacency (d < q).





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There are many options in the design of the mesh data structure in terms of the entities and adjacencies stored [4, 6, 13, 25] If a mesh representation stores all 0 d-level entities explicitly, it is a full representation, otherwise it is a reduced representation Completeness of adjacency indicates the ability of a mesh representation to provide any type of adjacencies requested without involving an operation dependent on the mesh size such as the global mesh search or mesh traversal Regardless of full or reduced, if all adjacency information is obtainable in O(1) time, the representation is complete, otherwise it is incomplete [4, 6, 25].

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In terms of the requirements to be the basic mesh data structure to be used for parallel adaptive computations, it must be able to provide all the mesh adjacencies needed by the operations to be performed and needs to be able to provide them effectively, which does require they be provided in O(1) time since any requirement to provide an adjacency in time at all proportional to the mesh size is not acceptable unless it is only done once Although this does not strictly require the use of a complete mesh representation, the wide range of adjacencies typically needed by mesh modi cation will force one to select a complete representation The implementation of a complete mesh data structure that is not full is more complex, particularly in parallel [28] The requirements placed on the mesh are a function of the parallel computing environment.

To ensure the greatest exibility, it is desirable to be able to distribute the mesh to the processors in a distributed memory computing environment with the need to store little more than the mesh entities assigned to that processor It is also a desirable feature that with the exception of possibly added information, the mesh data structure on the individual processors be identical to that of the serial implementation This way the parallel procedures can easily interoperate with a serial mesh structure implementation..

Another mechanism by which phages modulate their host range in situ entails the use of a reverse transcriptase to generate variation in tail ber proteins Liu et al (2002) identi ed a group of temperate phages that generate diversity in a gene, designated major tropism determinant (mtd), which speci es tropism for receptor molecules on host Bordetella species The infectious cycles of Bordetella subspecies, which cause respiratory infections in humans and other mammals, is controlled by the BvgAS signal transduction system (Uhl and Miller 1996) The Bvg1 phase, which is necessary for bacterial colonization, is characterized by a high level of BvgAS activity In the Bvg2 phase, BvgAS is inactive; the Bvg2 phase has been shown to be adapted to ex vivo growth and survival Liu et al.

8.5. EVALUATION OF A SOLUTION In Section 8.2, we introduced a simple job scheduling problem, where the Makespan was to be minimized for a given set of jobs and a given number of machines. However, in practical planning situations it is very rare that only one single objective function is used to evaluate the obtained solutions: In most practical situations, at

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