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, oral, nasal, pulmonary, transdermal, needle free) and the development of new biotechnological drugs have resulted in the need for enhanced protection against such factors as moisture, light, oxygen, and mechanical forces as well as making packaging play a more integral role in drug delivery [158] Novel drug delivery systems have necessitated the emergence of specialized packaging needs because not all of them can be packaged in bottles or standard blisters More often than not, the packaging must be unit dose and must also become an integral part of the drug delivery technology, as drug product packaging and packaging design contribute signi cantly to the stability, shelf life, and performance of the drug and the drug delivery system In fact, the old equation showing the relationship between a new chemical entity (NCE), drug delivery (DD), and drug product (DP) (ie.





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user applications. The exact method of providing QoS functionality in the backbone is left for the operators and manufacturers to choose. Backbone network services are implemented with generic (non-UMTS speci c) methods. Radio access bearer service: the service comprises QoS support for the entire RAN and its interfaces. It is realised by two distinct services: the radio bearer service and the Iu bearer service. Radio bearer service: the service covers all the aspects of radio interface transport. The UTRA FDD/TDD service provides the radio bearer service. UTRA FDD/TDD service: this service provides the transport between the UE and the RAN by means of the radio bearer service. For A/Gb mode, there are corresponding GSM/EGPRS physical radio bearer services. Iu bearer service: the service provides QoS handling by means of the physical bearer service between the RAN and the CN. Iu bearer services provide di erent bearer services with a variety of QoS characteristics. For A/Gb mode, the corresponding services are o ered over the Gb interface. Physical bearer service: this service provides the transport between the RAN and the CN. Terminal equipment/mobile termination local bearer service: this is responsible for the local QoS between the TE and MT. The TE and MT may be collocated in the UE, or the TE can be a separate device (e.g., laptop computer) that is connected to the MT (e.g., UE) providing the connection to the UMTS network. This QoS functionality is not further elaborated in R99 QoS speci cations.

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, NCE + DD = DP) is now being replaced by NCE + DD + packaging = DP Table 1 gives the considerations needed when designing packaging for new drug delivery systems [158] One of the stability problems associated with transdermal drug delivery devices is the degradation of the contents of the devices: drugs, permeation enhancers, matrix materials, and other components incorporated in the devices Degradation undesirably breaks down the components as well as causes discoloration and formation of odors within the pouched system Devices that are susceptible to degradation cannot be stored for a reasonable amount of time, thus causing practical problems in their distribution A solution to this problem involves the incorporation of an antioxidant such as BHT into the drug formulation of the transdermal drug delivery device [159] Also a desiccant has been incorporated within the sealed pouch of the transdermal drug delivery device.

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