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It is known that moisture transfer through packaging materials can affect hard gelatin capsules in two ways: changes in the properties of the shell and changes in the properties of the materials loaded in the capsule (contents of the capsules) Studies on capsules have recently examined the changes in both dissolution rates and potency of two brands of amoxicillin capsules packaged in PVC blister package (PVC blister having a thickness of 027 mm and aluminum base lm of thickness 27 m) and laminated type package (the laminated package consisting of three layers: a nitrocellulose lacquer outer layer, a soft aluminum lm intermediate layer, and a polyethylene inner layer) The two brands of amoxicillin stored outside the package at 76, 80, and 92% RH and inside the package at 92% RH showed no signi cant changes in dissolution pro les.



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Storage at 80 and 92% RH of the capsules of the two brands outside their packages resulted in a signi cant loss of amoxicillin potency The laminated-type package afforded better protection compared with the PVC aluminum blister package Following 20 weeks storage at 92% RH at room temperature, only 64% loss in amoxicillin potency occurred for capsules packaged in the laminated package compared with 518% loss in the blister package [97] The effects of two storage conditions (50 C, 50% RH and 40 C, 90% RH) on the properties (hardness, disintegration, tablet weight, dimensions, dissolution rate, and content of API) of two brands (A and B) of lm-coated erythromycin stearate tablets and one brand (C) of enteric-coated tablets of erythromycin base were examined The tablets were stored in paper bags, plastic dispensing bottles, and glass bottles.





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The ef ciency of an ampli er is limited by the saturation of the output power because of nonlinear voltage- and current-limiting phenomena. Before, the nonlinear behaviour was so strong as to cause output power saturation; however, the distortion can be so high as to degrade the quality of the signal beyond acceptable levels. Therefore, distortion must be de ned and evaluated, and usually is one of the design speci cations of a power ampli er. For a single-tone signal, a meaningful gure of merit of distortion is the harmonic content of the output signal. It is expressed as HD 2 = Pout (2f0 ) Pout (f0 ) HD 3 = Pout (3f0 ) Pout (f0 ) (4.23)

Aside from an increase in hardness by storage at 40 C, 90% RH for brand C tablets and a decrease in disintegration time for tablets of brand A under the same conditions, little or no changes were seen in most of the physical properties However, dissolution rates signi cantly decreased for all the tablets by storage under the two conditions Glass containers offered better protection for the tablets,.

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Media Center PCs can come equipped with a variety of optical drive con gurations, as shown in Table 5-2.

Figure 8-4: Using the Type menu to apply a Header 1 to the line where the cursor flashes. The pop-up menu at the left of the ruler contains the same heading formats and can also be used.

where the argument 8 has been reintroduced. Equation (4.95) is also a sufficient condition for r(w) to be unbiased since Ese = 0.Thus, (4.95) is a necessary and sufficient condition for r(w) to be unbiased for p(8) and to attain the Cram&-Rao lower bound. If p ( 8 ) = 8 and, therefore, r(w) = t(w), the necessary and sufficient condition for t(w) to be unbiased and to attain the Cram&-Rao lower bound is described by

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9 Find the new Toggle Snap Mode command in the Command List pane s list of commands and drag it to the Button 2 item You should see a small left-facing arrow pointing directly to the Button 2 item 10 Double-click Ctrl+Shift+Click in the Customizations In pane and click the Button 2 item Again click the New button in the Command List pane In the Name text box of the Properties pane, type Toggle Ortho Mode This lets you turn Ortho on and off using Ctrl+Shift+right-click (Notice that the Element ID is now MMU_0011) In the Macro text box, type ^O 11 Find the new Toggle Ortho Mode command in the Command List pane s list of commands and drag it to the Ctrl+Shift+Click Button 2 item You should see a small left-facing arrow pointing directly to the Button 2 item 12 Click OK to return to your drawing.

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