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clinician should take particular note of fevers, the patient s general sense of well-being, the presence of abdominal pain, the number of liquid bowel movements per day, and prior surgical resections Physical examination should focus on the patient s temperature, weight, and nutritional status, the presence of abdominal tenderness or an abdominal mass, rectal examination, and extraintestinal manifestations Most commonly, there is one or a combination of the following clinical constellations 1 Chronic inflammatory disease This is the most common presentation and is often seen in patients with ileitis or ileocolitis Patients report low-grade fever, malaise, weight loss, and loss of energy There may be diarrhea, which is nonbloody and often intermittent Cramping or steady right lower quadrant or periumbilical pain is present Physical examination reveals focal tenderness, usually in the right lower quadrant A palpable, tender mass that represents thickened or matted loops of inflamed intestine may be present in the lower abdomen 2 Intestinal obstruction Narrowing of the small bowel may occur as a result of inflammation, spasm, or fibrotic stenosis Patients report postprandial bloating, cramping pains, and loud borborygmi This sometimes occurs in patients with active inflammatory symptoms (as above) More commonly, however, it occurs later in the disease from chronic fibrosis without other systemic symptoms or signs of inflammation 3 Fistulization with or without infection A subset of patients develops sinus tracts that penetrate through the bowel and form fistulas to a number of locations Fistulas to the mesentery are usually asymptomatic but can result in intra-abdominal or retroperitoneal abscesses manifested by fevers, chills, a tender abdominal mass, and leukocytosis Fistulas from the colon to the small intestine or stomach can result in bacterial overgrowth with diarrhea, weight loss, and malnutrition Fistulas to the bladder or vagina produce recurrent infections Enterocutaneous fistulas usually occur at the site of surgical scars 4 Perianal disease One-third of patients with either large or small bowel involvement develop perianal disease manifested by anal fissures, perianal abscesses, and fistulas 5 Extraintestinal manifestations The extracolonic manifestations (described in the section on ulcerative colitis) may also be seen with Crohn s disease, particularly Crohn s colitis Other problems may also arise Oral aphthous lesions are common There is an increased prevalence of gallstones due to malabsorption of bile salts from the terminal ileum Nephrolithiasis with urate or calcium oxalate stones may occur.



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Inflammatory bowel disease is a lifelong illness that can have profound emotional and social impacts on the individual Patients should be encouraged to become involved in the Crohn s and Colitis Foundation of America (CCFA) National headquarters may be contacted at 444 Park Avenue South, 11th Floor, New York, NY 10016-7374; phone 212-685-3440 Internet address: http://wwwccfaorg

Figure 2-44

Insidious onset Intermittent bouts of low-grade fever, diarrhea, and right lower quadrant pain Right lower quadrant mass and tenderness Perianal disease with abscess, fistulas Radiographic evidence of ulceration, stricturing, or fistulas of the small intestine or colon





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One-third of cases of Crohn s disease involve the small bowel only, most commonly the terminal ileum (ileitis) Half of all cases involve the small bowel and colon, most often the terminal ileum and adjacent proximal ascending colon (ileocolitis) In 20% of cases, the colon alone is affected One-third of patients have associated perianal disease (fistulas, fissures, abscesses) A small number of patients have involvement of the mouth (aphthous ulcers) or upper intestinal tract Unlike ulcerative colitis, Crohn s disease is a transmural process that can result in mucosal inflammation and ulceration, stricturing, fistula development, and abscess formation Cigarette smoking is strongly associated with the development of Crohn s disease, resistance to medical therapy, and early disease relapse

Because of the variable location of involvement and severity of inflammation, Crohn s disease may present with a variety of symptoms and signs In eliciting the history, the

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