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Whenever he had problems with the factory on pricing, Bernie brought up the issue of the bottles in the warehouse Bernie told Sister that if the factory stuck with the prices as they were initially agreed on, he would do his best to take the bottles out of the warehouse Bernie was going to help, but only if the factory cooperated in other areas It all seemed too convenient for Johnson Carter that the factory was sitting on a large volume of product that had no use anywhere else Sister was upset about the bottles, but she was furious that they were being used in preventing her from making certain moves..



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Table A.3.1: Goal Extensions Name Goal Stereotype To Class Symbol Definition/Description Denote desired states, meaning that goals motivate actions leading to state changes in a desired direction. Something that prevents us from meeting goals. Cause, measure, and prerequisite are other stereotype notes that are useful when modeling problems. A cause leads to problems; a problem can be solved if the cause is removed. The cause can be removed if a certain measure is taken and certain





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that an unusual functional group called a cyanoguanidine had very similar physiochemical properties to a thiourea. Replacement of this latter group in metiamide by the cyanoguanidine function gave cimetidine, the potent orally active drug that for the rst time allowed pharmacological treatment of gastric ulcers (Fig. 9). The drug was also safe enough to nd broad use in the treatment of acid re ux. An unveri able account holds that the trade name Tagametw for cimetidine derives from the fact that the compound was supposedly being groomed as a follow-on successor to metiamide: thus Tag along Metiamide. New research programs at both Smith Kline and competitive laboratories were not long in exploring the breadth of the structural requirements for histamine H2 blockers. Chemists at Bristol Laboratories found that one of the hydrogens on the methyl groups of the cyanoguanidine could be replaced by an acetylene function (Fig. 10). Although this agent, etintidine,26 is a potent histamine H2 blocker, it is apparently not used clinically. A more profound change from work at the lab that rst produced cimetidine involved replacement of the cyanoguanidine function by a complex heterocycle. It is of note that the aminopyridone at the end of the side chain in oxmetidine27 incorporates a good part of the guanidine function in cyclized form. In a further demonstration of the looseness of structural requirement, chemists at Allen and Hanbury s were able to replace the ve-membered imidazole ring that had descended from histamine itself by a ve-membered, oxygen-containing furan ring. The basic nitrogen present in the original ring structure was carried on a carbon

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where N is the number of array elements and Larray is the array length. From (12.47) we notice that, c being a constant, the maximum scan angle 1 is not fixed for a Rotman lens but is a function of (almost inversely proportional to) the length of the radiating array Larray Interestingly, (12.47) indicates that the maximum scan angle in terms of the beam-width unit is fixed for a given Rotman lens (see problem 12.6). We obtain the solutions of the differential equations in (12.43) as r1 = c + R1 r2 = R r3 = c + R1 (12.48)

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Substance Abuse Narcissistic traits are frequently associated with abuse of alcohol, opiates (Calsyn, Fleming, Wells, & Saxon, 1996), cocaine and stimulants (Marlowe, Husband, Lamb, & Kirby, 1995; McMahon & Richards, 1996), and other substances Although the motives underlying substance abuse are often complex, two possibilities seem likely First, abuse of alcohol and other substances often provides relief from painful feelings By numbing their awareness, narcissists whose self-regard is under siege can temporarily put aside painful feelings of inferiority and self-doubt In fact, by turning reality aside, some may actually reinstate their cherished illusions of superiority and competence for a time Numbing negatives and reinstating positives thus make substance abuse doubly reinforcing However, the substance abuse is likely to depend on availability, peer group influences, and personality factors.

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