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signi cantly for up to 30 45 minutes after each cigarette. Synthesis of type I collagen has also been found to be reduced in smokers (Jorgensen et al., 1998). A review of the effects of smoking on wound healing by Siana et al. (1992) found that nicotine affected macrophage activity and reduced epithelialisation and wound contraction. There is increasing evidence that smoking is associated with poor wound healing and increased complications. However, most studies undertaken in this area have looked at surgical wounds and there is little information regarding smoking and chronic wound healing (Sorensen, 2003). Sorensen et al. (2002) studied the impact of smoking compared with nonsmoking on 425 patients undergoing breast surgery. They found smoking was signi cantly associated with wound infection, skin ap necrosis and epidermolysis. The same group studied the impact of abstinence from smoking on healing of experimental incisional wounds in healthy individuals. They compared never-smokers with smokers randomised to either continue smoking or abstain from smoking for a four-week period. They found a signi cantly higher incidence of wound infection in the smokers compared with the never-smokers (12% versus 2%, p < 0.05). They also found there was a signi cant reduction in infection in the abstinent smokers compared with continuous smokers (Sorensen et al., 2003). Manassa et al. (2003) undertook a retrospective study of 132 patients undergoing abdominoplasty and compared outcomes for smokers and non-smokers. They found a signi cant incidence of wound complications, including wound dehiscence (47.9% versus 14.8%, p < 0.01). In reviewing the evidence on smoking and problems in wound healing, Sorensen (2003) suggests that there is a need for research into the impact of smoking on chronic wound healing. Further research is also required to determine the impact of abstinence on collagen production and delayed healing.

Meta-associations type, general, speci c, supplier, client, contract, ownedParameter, ownedAttribute(2), ownedOperation(2), memberEnd, implementingClassi er Constants Enumeration values in, out, inout, return, none, shared, composite, bTrue, bFalse, public, private, protected, package

When j i ---------------------------First line 0 0 Start of loop 0 1 After first loop 1 1 Start of second loop 1 2 After second loop 3 2 Start of third loop 3 3 After third loop 6 3 Start of fourth loop 6 4 After fourth loop 10 4 Start of fifth loop 10 5 After fifth loop 15 5

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De nition 4.3.5 introduces the universes UCLASS of class names, UOID of object identi ers, and INSTANCE of instances. A class name is associated with a nite set of attributes, which simply are variables. Each class name is, moreover, associated with a set of object identi ers. By use of the association mechanism (see Section 4.3.7), class names can be related to each other. Also, methods can be associated with class names; see De nition 4.4.2.

In the Coordinates rollout for 2D Maps, shown in Figure 25-2, you can specify whether the map will be a texture map or an environment map. The Texture option applies the map to the surface of an object as a texture. This texture moves with the object as the object moves. The Environ option creates an environment map. Environment maps are locked to the world and not to an object. Moving an object with an environment map applied to it scrolls the map across the surface of the object.

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Use low temperatures. Cheese contains a high proportion of protein, which toughens and becomes stringy when heated too much. Sauces containing cheese should not be boiled. Use short cooking times, for the same reasons. Cheese should be added to a sauce at the end of cooking. Stirring it into the hot sauce off the heat is usually enough to melt it. Grate cheese for faster and more uniform melting. Aged cheeses melt and blend into foods more easily than young cheeses. Aged cheese adds more avor to foods than young, mild cheeses, so you need less of it.

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