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Measurement Tracking In addition to tracking the pass test rates during system testing, tracking of performance and load stress testing should be started as soon as the corresponding modules are completed. If the results of such tests are collected over an extended time and compared against a baseline, undesired performance drops can be easily detected and eliminated as soon as they are introduced. For example, before adding the security layer to a module, performance testing should be conducted and the results should be saved as a baseline. After adding the security layer, performance testing should be repeated, and the results compared with the baseline to see whether the added functionality degrades the performance. If the performance degradation is unacceptable, the security layer may need to be modi ed. Automation

In particular, those that focus on phonological awareness have been shown to result in increased activation bilaterally of the inferior frontal gyrus with resulting L > R asymmetry consistent with that found in controls Alternatively, following intensive intervention, changes have included increased activity in the left temporoparietal region as well as a change in the timing of activity in the temporoparietal and frontal regions (Simos et al, 2006) Increased activation of the occipitotemporal, temporoparietal, and inferior frontal areas was found in response to a simple phonologic task following intervention with the Fast ForWord program (E Temple et al, 2003) Others have found that with orthographic training, there is normalization of activation to the right inferior frontal gyrus and right posterior parietal gyrus (Richards, Aylward, Berninger et al, 2006).

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Once an online conversational community has demonstrated its effectiveness within an organization, circumstance 1 is instantly transformed into circumstance 2, with experiential evidence to support the proposal A track record and a functioning prototype will increase the chances of the proposal being approved The leap in effectiveness from conversations using email to conversations using a well-designed message board with content management can be significant depending on the group and the nature of its knowledge exchange The proposal must outline how the current technology is holding the community back from achieving its potential The specific gains that can be realized through better supported conversation must be detailed As described in 7, Choosing and Using Technology, there is a wide range of software and platforms appropriate for knowledge networks.

Genetics will fundamentally change the practice of medicine and the process of drug development. The timing of this massive change is not certain; however, it is likely to occur in the next 5 10 years. The reasons for the change include the evolution of the science and technology in the elds of the human genome, single-nucleotide polymorphism (SNP) maps, genotyping, and bioinformatics. We are living through a momentous time when the convergence of scienti c and technological developments has resulted in the possibility of new approaches to unraveling the mysteries of disease and health. DNA was described less than 50 years ago. In 2000, the draft sequence of the entire human genome was released by the Human Genome Project (HGP), a publicly funded effort, and Celera, a privately held company. Through the discoveries enabled by the HGP, the SNP Consortium (a group of 11 pharmaceutical companies, 5 academic centers, 2 information technology companies, and the Wellcome Trust) expanded the map of the genome that had been used for the past 10 years from 400 markers to 1.7 million markers. The impact of this new map can be imagined in the following way. If you think of the distance from New York to California as the genome, the road signs would change from one every 7.5 miles to one every 9 feet. The markers (or road signs) are SNPs. The SNP Consortium released the map into the public domain so that anyone doing gene mapping experiments could use this new SNP map. The original 400 markers were dif cult to

The scale of the conversational community must be large enough to justify the most expensive platforms by spreading out the costs over more users There may be substantial costs for integrating the platform into the existing technology There will be costs in training and refining the design once the platform is in use A joint proposal representing the needs of other groups within the organization stands a better chance of approval There may be many other groups expressing the same needs to engage online through better software and wanting more training or more time to spend in online collaboration The more groups that are allied behind the proposal, the more leverage there is for getting necessary funding Be willing to compromise and accept software solutions that are less than perfect, at least as an interim concession.

If the polymorphism occurred generations after the causal mutation, some people would have the responsible mutation but not the polymorphism. A test for the polymorphism in them would fail to predict altered drug handling. Mutations leading to loss of function of some CYP2D6 alleles may have occurred before the origin of some CYP2D6 haplotypes observed today (Kalow and Grant, 1995).

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