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sesquiterpenes had been isolated from the aerial part of A annua and brie y summarized by Zaman and Sharma4 Four additional sesquiterpenes include the b-epoxy isomer of arteannuin B (24),46 6-epi-deoxyarteannuin B (25),47,48 11,13dehydro-qinghaosu artemisitene (26),49 and 6,7-dehydro-artemisinic acid (27)47 Qinghaosu (1) can be classi ed as a cadinane sesquiterpene oxygenated at the 12-position; the other 15 cadinanae sesquiterpenes share this common structural feature (see Table 5-1, Nos 1 16) A new sesquiterpenes called artemisinin G (28) was puri ed from A annua shortly after the Zaman and Sharma brief review by Chinese scientists in 1992.



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50 Because the authors found that compound 28 was a decomposition product of qinghaosu by heating at 190 C for 10 min, or in re uxing xylene for 22 h, the possibility that artemisinin G (28) could be an artifact during the isolation procedure was eliminated through a heating experiment with qinghaosu that mimicked the isolation process A new member of the unusual cadinanolide series of sesquiterpenes, annulide (29), was described in 1993 with its structure and relative con guration determined by nuclear magnetic resonance (NMR) results, although the sample was limitedly puri ed51 Meanwhile the closely related structure isoannulide (30) was also described in the same article with poor purity; the complete and unambiguous NMR spectral assignments for isoannulide (30) were presented in a later article by the same author.

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52 Three other structural relatives of artemisinin B (10), 31,53 32,54 and 6a-hydroxyisoannulide (33),55 were recorded in 1987, 1992, and 1994, respectively Known as an acid hydrolysis product of artemisinin B (arteannuin B, 10) based on an earlier synthetic research, compound 33 was checked by thin-layer chromatography (TLC) analysis of the crude extract and proved to be the endogenetic natural product from A annua other than an artifact during puri cation A bisnor-sesquiterpene, norannuic acid (34) was reported in 1993,56 and three new cadinane sesquitepenes (35 37) were isolated and reported in 1994, both by Ahmad and Misra57 Compound 37 is of interest in that a 3-isobutyryl group was discovered for the rst time in cadinane sesquiterpenes from A annua.

Brown described compound 38 (a pair of isomers), 39 in 1994,58 and Sy and Brown described another new cadinane sesquitepene (40) in addition to a new eudesmane sesquiterpene (41) from the aerial parts of A annua in 199859 Compound 40 is unique in that it is oxygenated at the 7-position rather than at the 12-position found in most other cadinanes isolated from this species Compound 41 is a 5a-hydroxyeudesmane incorporating an allylic tertiary hydroxide group evidenced by the results of HREIMS and 1D/2D-NMR, which is also a 5-hydroxy derivative of trans-b-selinene previously identi ed from A annua growing in the United Kingdom51 Seven new sesquiterpenes, including a peroxylactone arteannuin H (42) and arteannuin I M (43 48), were isolated by the same research group in 1998.

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