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The Java API for XML Registries (JAXR) project at Sun Microsystems is an API that provides standard access methods that can be used to communicate with registries to build, deploy, and locate Web services. It is intended to be a single API that can be used as an abstraction for any number of existing APIs that are currently used for access to various registries. Several, somewhat overlapping, registry definitions exist, such as OASIS, eCo Framework, ISO 11179, ebXML, and UDDI. Each of these registry systems has its own API, and JAXR is intended to be an umbrella API to make them all look the same to your application. JAXR is also intended to provide interoperability to a set of open registries that otherwise cannot exchange information. The information from one registry can be stored as a Java object and shared with other registries. Currently, extending the capabilities of all registries by providing a clean path of communication among them is being planned. The same API can be used to extract information from one and store it into another. The current JAXR development is for an optional package for use with Java 2, but it could possibly be added as part of a future version of the Java 2 Enterprise Edition.



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1. Start Network Settings. Click System Administration Networking. The Network Settings window appears. 2. Select the Ethernet connection entry on the screen for the interface you want to configure and click Properties. The first Ethernet card should be identified as eth0 (if other Ethernet cards are present, they will be identified as eth1, eth2, and so on). The Interface properties window appears, as shown in Figure 5-7.





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for designing potent novel inhibitors have been undertaken based on the available 3-D structures of the inhibitor-AChE complexes132 135,142,143,151 156 Considering that the bridgehead amino group of HA is not part of a direct interaction with TcAChE, Hogenauer et al prepared 5-desamino HA (25j) and revealed that it had 100-fold less activity than HA, which indicates that the amino functionality is necessary for biological activity119 The x-ray crystal structures of tacrine-TcAChE157 and ( )-HA-TcAChE144 complexes indicate that the binding sites for tacrine and ( )-HA within TcAChE are adjacent and partially overlapped158 Camps et al155 designed a series of huprines (38 41 and 49), which combine the probable pharmacophores of ( )-HA and tacrine The synthesis and bioassay of these hybrids have been reviewed in Section 4-6.

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A special method, setNull(), enables you to use the null value in a query. Theoretically you can expect better performance from the PreparedStatement class than from the Statement class, but in real life performance varies depending on the vendor s implementation of the particular JDBC driver.

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Of the series, huprine X 49a showed the highest potency, which inhibited hAChE with an inhibition constant, Ki, of 26 pM, being about 180-fold more potent than ( )-HA and 1200-fold more potent than tacrine151 To explain the SARs at a more quantitative level, Camps et al performed a molecular modeling study on a series of huprines152 The predicted free energy values are in general agreement with the inhibitory activity data of these inhibitors, and the modeling results rationalized the binding modes of these compounds to AChE The crystal structure of 49a com plexing with TcAChE was determined by Dvir et al at 21 A resolution158 In general, huprine X binds to the anionic site and hinders access to the esteratic site.

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environment For rats in cages, and for humans in industrialized societies, the quest for dopamine can get us into serious trouble In Austin Powers, our hero, the international man of mystery, says, Only two things scare me, and one of them is nuclear war Similarly two things scare me about our human stimulus-response system, and one of them is drug addiction While some people s lives are destroyed by the maladaptive activation of the stimulus-response system by drugs, almost all of us lose money because of its effects on our finances We are built to seek the dopamine high that comes from successes For our ancestors, this system led them toward useful behaviors In the financial world, however, this system is almost perfectly designed to create poverty Investing is a changing game where the best strategy today is almost never the best strategy of yesterday.

Its aromatic portion occupies the same binding site as tacrine, stacking between the aromatic rings of Trp84 and Phe330, whereas the carbobicyclic unit occupies the same binding pocket as ( )-HA Its chlorine substituent was found to lie in a hydrophobic pocket interacting with the rings of the aromatic residues Trp432 and Phe330 and with the methyl groups of Met436 and Ile439 The complexes of TcAChE with such bisquatrnary ligands as decamethonium [DECA, Me3N (CH2)10N Me3]157 and BW284C51159 led to the assignment of Trp279 as the major element of a second, remote binding site, which is near the top of the active-site gorge, named the peripheral anionic site, about 14 A apart from the active site These structural assignments promoted the development of bivalent AChE inhibitors 42 46 capable of binding sites simultaneously to improve drug potency and selectivity.

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