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So our brains are built to replicate successful behaviors, but the financial markets punish such behavior Those who invest by stimulus-response will tend to do that which has worked, not that which will work For example, after the huge stock market gains in the 1990s, investors ploughed a record $309 billion into stock mutual funds in 2000, just in time for the stock market bubble to burst Over the two years of 2001 and 2002, investors invested a total of just $4 billion into stock funds, again timed perfectly to miss the huge stock market rally in 2003 In 2003, investors ploughed over $150 billion into equity funds4 To date, stocks have lost ground in 2004 (through midJuly) The backward-looking, stimulus-response system of investing is not profitable On a far grander scale, we have been rewarded for taking financial risk for a generation.



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133 135,156 The rst example of bivalent inhibitors is the heptylene-linked tacrine dimer, bis(7)-tacrine, designed and synthesized by Pang et al on the basis of computational studies134 Bis(7)-tacrine showed signi cantly higher potency and selectivity for inhibition of rat AChE than did monomeric tacrine134,156 Later on, Carlier et al designed and synthesized the bivalent inhibitors 42 that are composed of a key fragment of HA and an intact tacrine unit133 The most active compound in this series is 13-fold more potent than HA and 25-fold more potent than tacrine; however, their selectivity is lower than HA Also, Carlier et al135 designed and synthesized a series of dimers 43 of hupridone, an easily synthesized but pharmacologically inactive fragment of ( )-HA on the basis of docking modeling.





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where cl = [cl1 cl2 ] is the vector of channel gains corresponding to the l th receive antenna in any single block (two-symbol) interval. Hence, replacing cl by cl and T T by N and then applying Turin s result, it can be shown that n n=1 n the PEP now becomes exp Lr K 1+

A spray diagram is used to record ideas about relationships in the very early stages of analysis, often as a preliminary to drawing a relationship diagram or a multiple-cause diagram. Figure 6.5 shows a spray diagram centred on Cambridge University s need to update their computerized accounting systems to incorporate commitment accounting. The diagram includes both the attempted in-house development and the implementation of the off-the-shelf software. It shows one interpretation of the way various factors

Although these HA-like dimers are not as potent as bis(7)-tacrine or the tacrine HA fragment heterodimer on rat AChE, being only 2-fold more potent than ( )-HA for the most active compound, they are superior to the latter dimers in terms of selectivity for AChE160.

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For Further Exploration: How do knowledge requirements of bank employees differ from those of bank customers How would these differences in uence the functionality of knowledge management systems designed to serve these two groups of users

BevelBitmapEffect bbe = new BevelBitmapEffect(); Rectangle.BitmapEffect = bbe; LinearGradientBrush lgb = new LinearGradientBrush(Colors.White, Colors.DarkGray, 45); Rectangle.Fill = lgb;

9 from an ASCII keyboard interfaced to it and output to an EBCDIC printer. Assume that the keyboard is connected to port A and the printer is connected to port B. Store the EBCDIC codes for 0 to 9 starting at an address $003030, and use this look-up table to write a 68000 assembly language program to accomplish the above.

Note that, just as in conventional FEC techniques, the implementation of "soft-detection" sampling (e.g. with two or three bits per sample) can improve by about 2 dB the performance (Eb/N0 for a given BER), compared to the "harddetection" with single-bit samples.

Fumarate is hydrated by cytosolic fumarase to form malate, which is oxidized to oxaloacetate, and then transaminated to regenerate aspartate.

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In the previous chapter we described how traditional approaches to modeling cognition have focussed on what goes on inside one person's head. We also mentioned that there has been considerable dissatisfaction with this approach, as it ignores how people interact with one another and their use of artifacts and external representations in their everyday and working activities. To redress this situation, Ed Hutchins and his colleagues developed the distributed cognition approach as a new paradigm for conceptualizing human work activities (e.g., Hutchins, 1995) (see Figure 4.15). The distributed cognition approach describes what happens in a cognitive system. Typically, this involves explaining the interactions among people, the artifacts

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