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Whenever the authors want to bring something important to your attention the information will appear in a Tip, Note, or Caution.

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occurs from (1) an ipsilateral lateral pterygoid myospasm bracing the condyle in a translated position, and/or (2) an in amed ipsilateral retrodiscal tissue causing the lateral pterygoid muscle to contract and hold the condyle in a partially translated position so as not to impinge the in amed retrodiscal tissue As one bites into maximum intercuspation (MI), the teeth force the condyle posterior and can cause pain by stretching the myospasm and/or impinging the in amed retrodiscal tissue When individuals have a lateral pterygoid myospasm (similar to a spasm in the calf muscle), they cannot stretch the muscle (for the teeth occlude into MI) and they cannot contract the muscle (for the condyle to translate) The inability to translate the ipsilateral condyle causes them to have a limited opening and contralateral movements, as with this patient having a 25 mm opening and 8/4/6 (right lateral, left lateral, and protrusive).





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Clinically, the degree to which this occurs varies with the severity of the lateral pterygoid myospasm Limited translation can also occur with TMJ in ammation The patient was asked to lie back in the dental chair, relax her mandible with it slightly open, and close her teeth together slowly It was observed that her left canines were repeatedly the rst teeth to contact, even though her teeth appeared to have normal alignment This further suggests the right condyle is in a partially translated position Palpation of her masticatory and cervical structures revealed generalized tenderness of the masticatory structures, with the greatest tenderness in the right lateral pterygoid area, followed by the bilateral masseter, anterior region of the temporalis muscles, and left lateral pterygoid area, then followed by the TMJs Masticatory palpations reproduced her pain.

Robert Pardo (Pardo 1992) formulated a definition of potential profit and an algorithm of its computation in this statement: Potential profit is the profit that could be realized by buying every bottom and selling every top. More precisely, it is the sum of every price change where each change is taken as a positive number. Are the first and second sentences in agreement Yes, they are if we assume that selling every top means short selling so that the result of this transaction is a net short position in the market. In other words, if we were long one unit (a contract or share) before the transaction, then the transaction liquidates the long position and enters a new short position at the same price. The same process occurs when buying every bottom. We are always

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Pharmacokinetic studies are in principle set up in the same way as stability studies, but with one major difference: Stability studies have the goal of testing how stable the product is on the shelf, to determine the shelf-life. Pharmacokinetic studies are used to test how the body breaks the product down and disposes of it. Various body uids are tested to nd the product or its metabolites (breakdown products) over a shorter period of a few hours or a number of days. The uids (blood, urine, feces, or others) are collected at certain time points and analyzed. 18.18.1 Pharmacokinetic Study Functionality in a LIMS

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