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These authors go on to suggest that most women in Europe are iodine de cient during pregnancy and they recommend that all pregnant women should receive iodine-containing supplements (150 g/day) during pregnancy According to the WHO, as many as 16 billion people in the world live in places where they are at risk of iodine de ciency They rely on local food, grown in mountainous areas or frequently ooded river valleys where the soil iodine content is low (the Andes, the Himalayas, the Ganges river valleys, the mountainous areas of China) It is further estimated that around 200 million people suffer from goitre and maybe 10% of these show signs of resultant mental de cits More than 5 million people worldwide suffer from gross cretinism and severe mental retardation Iodine de ciency is the most common preventable cause of mental subnormality in children.



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Mean intakes of iodine from food in the UK are 220 g/day with the highest consumers taking in around double this amount It is estimated that in some parts of the UK drinking water may provide up to a maximum of a further 30 g/day Iodine is a component of many vitamin and mineral multi-supplements and is present in kelp or other products of marine origin, but it is rarely used as a single supplement in western countries; these supplements may provide up to 490 g/day making a total estimated maximum exposure of 950 g/day (FSA 2003) Iodine is a component of a number of medicinal products used for topical application because of its antiseptic properties Some people are allergic to iodine used in this way and occasional cases of acute poisoning have resulted from accidental consumption of these products or their use in, for example, wound irrigation.

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Calibration means the passive observation of the calibration status without any action. Setting the calibration status to zero or to some other conventional value is called adjustment. Nevertheless, once a calibration is performed, the calibration error is kept in due consideration either by a physical adjustment or by a software a posteriori correction of the successive measures. Therefore, we speak of calibration interval independently if it is followed by a physical or software adjustment, meaning the time interval at which the calibration condition of a measuring instrument is measured and its value is taken into account for the subsequent measurements. Let us suppose that the measuring instrument at hand is kept under stochastic control, according to the methods explained in the previous sections, by means of repeated measurements of check standards, whose results are registered on a control chart as in Figure 6.2. Two calibration interval determination policies can be considered. In the first policy, the measuring instrument is always kept under stochastic control and the calibration condition is almost continuously monitored on a control chart. The recalibration is only performed when deemed necessary, for example when the calibration condition exceeds an alert threshold m , which is fixed below the limit of permissible errors a , as depicted in Figure 6.3.

High intakes of iodine can lead to disturbances in thyroid function This usually manifests as toxic nodular goitre and hyperthyroidism but can sometimes manifest as hypothyroidism as would be expected in iodine de ciency These symptoms occur in populations who have chronically high iodine intakes or where there has been active.

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