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Spontaneous bacterial peritonitis must be distinguished from secondary bacterial peritonitis, in which ascitic fluid has become secondarily infected by an intra-abdominal infection Even in the presence of perforation, clinical symptoms and signs of peritonitis may be lacking in up to 30% of patients owing to the separation of the visceral and parietal peritoneum by the ascitic fluid Causes of secondary bacterial peritonitis include appendicitis, diverticulitis, perforated peptic ulcer, and perforated gallbladder Secondary bacterial infection accounts for 3% of cases of infected ascitic fluid Ascitic fluid total protein, LDH, and glucose are useful in distinguishing spontaneous bacterial peritonitis from secondary infection Up to two-thirds of patients with secondary bacterial peritonitis have at least two of the following: decreased glucose level (< 50 mg/dL), an elevated LDH level (greater than serum), and total protein > 1 g/dL Ascitic neutrophil counts > 10,000/mcL also are suspicious; however, most patients with secondary peritonitis have neutrophil counts within the range of spontaneous peritonitis The presence of multiple organisms on ascitic fluid Gram stain or culture is diagnostic of secondary peritonitis If secondary bacterial peritonitis is suspected, plain films, abdominal CT imaging, and water-soluble contrast studies of the upper and lower gastrointestinal tracts should be obtained to look for evidence of an intra-abdominal source of infection If these studies are negative and secondary peritonitis still is suspected, repeat paracentesis should be performed after 48 hours of antibiotic therapy to confirm that the PMN count is decreasing Secondary bacterial peritonitis should be suspected in patients in whom the PMN count is not below the pretreatment value at 48 hours Neutrocytic ascites may also be seen in some patients with peritoneal carcinomatosis, pancreatic ascites, or tuberculous ascites In these circumstances, however, PMNs account for less than 50% of the ascitic white blood cells



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The mortality rate of spontaneous bacterial peritonitis exceeds 30% However, if the disease is recognized and treated early, the rate is less than 10% As the majority of patients have underlying severe liver disease, many may die of liver failure, hepatorenal syndrome, or bleeding complications from portal hypertension





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% File describing the power system of Problem 13-8b, including % resistances % % System data has the form: %SYSTEM name baseMVA SYSTEM Prob13_8b 100 % % Bus data has the form: %BUS name volts BUS One 100 BUS Two 100 BUS Three 100 BUS Four 100 % % Note that transformers T1 and T2 are treated as "transmission lines" % here Transmission line data has the form: %LINE from to Rse Xse Gsh Bsh X0 Vis LINE One Two 00100 00500 0000 0000 00500 3 LINE Two Three 01240 06198 0000 0000 10331 3 LINE Three Four 00238 01190 0000 0000 01190 0 % % Generator data has the form: %GENERATOR bus R Xs Xp Xpp X2 X0 GENERATOR One 010 090 020 010 010 005

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Caruntu FA et al Spontaneous bacterial peritonitis: pathogenesis, diagnosis, treatment J Gastrointest Liver Dis 2006 Mar; 15(1):51 6 [PMID: 16680233] Ghassemi S et al Prevention and treatment of infections in patients with cirrhosis Best Pract Res Clin Gastroenterol 2007;21(1):77 93 [PMID: 17223498] Planas R et al Natural history of patients hospitalized for management of cirrhotic ascites Clin Gastroenterol Hepatol 2006 Nov;4(11):1385 94 [PMID: 17081806] Sheer TA et al Spontaneous bacterial peritonitis Dig Dis 2005; 23(1):39 46 [PMID: 15920324]

Up to 70% of patients who survive an episode of spontaneous bacterial peritonitis will have another episode within 1 year Prophylactic therapy with norfloxacin, 400 mg/d; ciprofloxacin, 750 mg weekly; or trimethoprim-sulfamethoxazole, one double-strength tablet daily has been shown to reduce the rate of recurrent infections to less than 20% and is recommended Prophylaxis should be considered also in patients who have not had prior bacterial peritonitis but are at increased risk of infection due to low-protein ascites (total ascitic protein < 1 g/dL) Although improvement in survival in cirrhotic patients with ascites treated with prophylactic antibiotics has not been shown, decision analytic modeling suggests that in patients with prior bacterial peritonitis or low ascitic fluid protein, the use of prophylactic antibiotics is a cost-effective strategy

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