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static method retrieve implemented easily using the ppf.com.utils.retrieve function, the Python built in staticmethod function and partial function application achieved with a expression (isn t Python wonderfully expressive ). The retrieve method is not part of the COM interface of class MarketServer, it is there for interaction between the servers, on the Python side. The use of a class static data member to hold the environments makes the design of class MarketServer an example of a mono-state pattern; all instances share the same state and are therefore equivalent. Excepting the retrieve function, the remaining methods of class MarketServer satisfy its COM interface. CreateEnvironment The CreateEnvironment method takes a user-supplied name for an environment, a COM date (the pricing date for the market), creates an empty class environment instance, stores it in the environments dictionary for later retrieval and simply returns the user provided name for the environment to indicate success. Should the operation fail for any reason, the Python exception is caught and a COM exception raised by means of the ppf.com.utils.raise com exception function. This exception handling idiom at the Python/COM boundary (explained in section 12.1) will be the same for every COM interface method and we will refrain from remarking on it again going forward. AddCurve The AddCurve function injects a user-supplied curve into the named market environment. We will look at this function in a little more detail:



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no longer detected by sensitive HPV testing within 6 to 9 months from the rst positive HPV test A study by Rodriguez and colleagues estimated that 67% of infections clear by 12 months Younger patients were more likely to clear infection than women over the age of 30 years7 Regression of cervical neoplasia occurs most frequently with low-grade lesions Between 70% and 90% of CIN 1 lesions and 40% of CIN 2 lesions will resolve spontaneously8 These patients will also test negative for high-risk HPV within 6 to 24 months High-grade cervical neoplasia is more likely to develop in the face of persistent HPV infection and particular HPV types In a prospective study using HPV testing in conjunction with cervical biopsy, 33 out of 353 women reached clinical progression to CIN 3 and all had persistent infection with highrisk HPV.





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9 When CIN 3 is detected, progression to invasive cancer can occur over a period that averages 10 years It occurs over an extended period of time as cervical cells accumulate the mutations required for invasion The HPV virus is a double-stranded DNA virus that induces epithelial cell proliferation or papillomas There are over 100 different types of HPV; about 40 types infect the genital tract Each type varies by a portion of its DNA genome and is divided into two groups The low-risk HPV types are associated with benign changes such as condyloma The high-risk types are known as oncogenic types and are detected in CIN and cervical cancer These oncogenic types incorporate their DNA into the genome of human cells and block the cell s ability to repair or destroy itself when it begins to accumulate mutations.

substrate is conductive, the reduction product, R, at the tip is re-oxidized at the substrate and O is regenerated. The regenerated O is then reduced again at the tip. The efficiency of this cycle depends on the ratio of (d/a), where a is the radius of the disk-type tip electrode and d is the distance of the tip from the substrate. The tip current iT is a function of L : (d/a) as approximately described by: IT L iT =it;I 0:68 0:78377=L 0:3315 exp 1:0672=L where iT, is the tip current at (d/a) . The tip current at any potential, E, can be expressed by Eq. (9.4) when the tip reaction is reversible, and by Eq. (9.5) when the tip reaction is under mixed diffusion-kinetic control: IT E; L 0:68 0:78377=L 0:3315 exp 1:0672=L =h IT E; L 0:68 0:78377=L 0:3315 exp 1:0672=L = h 1=j 9:4 9:5

All human papilloma viruses contain seven early genes (E1 E7) and two late genes (L1 L2), depending upon where they fall in the genomic sequence of the virus E6 and E7 are known oncogenes of the highrisk types of HPV They produce proteins that inhibit human tumor suppression genes, notably p53 and Rb E6 protein binds and inactivates p53, a protein that is responsible for repairing damaged DNA or apoptosis (programmed cell death) in damaged human cells E7 protein binds primarily to pRB (retinoblastoma gene), which is responsible for stopping DNA synthesis in a damaged cell These oncoproteins deregulate cell proliferation, thus pro-.

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