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After the discovery of the anisotropies by the COBE satellite, which only probed the largest angular scales, most observers turned their attention to probing the structure predicted on smaller angular scales, requiring higher-resolution experiments While many experiments contributed towards this goal, it is widely recognized that the landmark step was made in April 2000 with the announcement of results from the Boomerang experiment This was an ingenious experiment carried around Antarctica on a high-altitude balloon by wind currents, in order to maximize observation time (around fourteen days) while minimizing contamination from the atmosphere This experiment clearly picked out the first broad peak, locating it at l' ':: 200, the significance of which will be explored in the following subsection It was rapidly followed by independent confirmation from another balloon experiment, called Maxima.



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Subsequently, more detailed analysis of these observations, along with results from new experiments, began to pick out the peak structures at larger e Experiments carried out on Earth or on high-altitude balloons can have high precision, but their statistical power is limited by being able to survey only small areas of sky In February 2003, spectacular results were announced by the WMAP satellite project The true successor to COBE, this mission combined sensitive detectors with full sky coverage at a resolution approaching 10 arcminutes The measurement of the radiation angular power spectrum based on their first year of observations is shown in Figure A54 A comparison with Figure A53 (noting the different i-axis scaling) shows that these observations agree extremely well with expectations The solid line in Figure A5.





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4 is the prediction from the cosmological model best fitting their data, whose parameters match those of the Standard Cosmological Model within their uncertainty The band indicates the statistical uncertainty from cosmic variance, which is most important on large angular scales The conclusion is that our current cosmological models are very much on the right track, a remarkable vindication of theoretical predictions which were already in place long before any microwave anisotropies were measured Those anisotropies are now the most powerful observational tool for constraining cosmological models..

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and suffer from sympathomimetic side effects. Phenylpropanolamine was withdrawn because of an increased risk of stroke in young women, and ephedrine/caffeine because of unresolved concerns about safety and lack of ef cacy. The medical establishment abandoned thyroxine as a treatment for obesity in euthyroid subjects in the 1920s, but it has still been used for this purpose; iatrogenic hyperthyroidism can cause life-threatening (and medicolegally indefensible) arrhythmias. This historical background highlights the great challenges faced by researchers and the pharmaceutical industry when attempting to develop safe and effective anti-obesity drugs. It has also shaped the context in which new drugs are evaluated and regulatory decisions made. Key considerations include the drug s ef cacy in reducing weight and whether this is clinically signi cant, its ability to maintain weight loss, its impact on the comorbidities of obesity, and the balance between its bene ts and any adverse effects.

You probably won t use static variables that often, and you can often achieve the same effect (albeit with greater risk) using global variables. However, when you do really need to create a static variable you ll probably be thankful that they exist. They re often used with recursive functions (which you learn about later in this chapter) to remember values throughout the recursion.

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74. R. A. Rakuljic, K. Sayano, A. Agranat, A. Yariv, and R. R. Neurgaonkar, Photorefractive properties of Ce- and Ca-doped SBN, Appl. Phys. Lett. 43, 1465 1467 (1988). 75. A. Gerwens, M. Simon, K. Buse, and E. Kratzig, Activation of cerium-doped strontiumbarium niobate for infrared holographic recording, Opt. Commun. 135, 347 351 (1997). 76. S. G. Odoulov, A. N. Shumelyuk, U. Hellwig, R. A. Rupp, and A. A. Grabar, Photorefractive beam coupling in tin hypothiodiphosphate in the near infrared, Opt. Lett. 21, 752 754 (1996). 77. S. G. Odoulov, A. N. Shumelyuk, U. Hellwig, R. A. Rupp, A. A. Grabar, and I. M. Stoyka, Photorefraction in tin hypothiodiphosphate in the near infrared, J. Opt. Soc. Am. B 13, 2352 2360 (1996). 78. S. G. Odoulov, A. N. Shumelyuk, G. A. Brost, and K. M. Magde, Enhancement of beam coupling in the near infrared for tin hypothiodiphosphate, Appl. Phys. Lett. 69, 3665 3667 (1996). 79. C. Medrano, M. Zgonik, I. Liakatas, and P. Gunter, Infrared photorefractive effect in KNbO3 crystals, J. Opt. Soc. Am. B 13, 2657 2661 (1996). 80. M. Ewart, R. Ryf, C. Medrano, H. Wuest, M. Zgonik, and P. Gunter, High photorefractive sensitivity at 860 nm in reduced rhodium-doped KNbO3, Opt. Lett. 22, 781 783 (1997).

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