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Immunoassays that use an antibody to the glycated amino terminus of globin do not recognize the terminus of the globin of hemoglobin F Thus, in patients with high levels of hemoglobin F, immunoassays give falsely low values of HbA1c Cation-exchange chromatography separates hemoglobin species by charge differences Hemoglobin variants that co-elute with HbA1c can lead to an overestimation of the HbA1c value Chemically modified derivatives of hemoglobin such as carbamoylation (in renal failure) or acetylation (highdose aspirin therapy) can similarly co-elute with HbA1c by some assay methods Any condition that shortens erythrocyte survival or decreases mean erythrocyte age (eg, recovery from acute blood loss, hemolytic anemia) will falsely lower HbA1c irrespective of the assay method used Alternative methods such as fructosamine (see below) should be considered for these patients Vitamins C and E are reported to falsely lower test results possibly by inhibiting glycation of hemoglobin c Serum fructosamine Serum fructosamine is formed by nonenzymatic glycosylation of serum proteins (predominantly albumin) Since serum albumin has a much shorter half-life than hemoglobin, serum fructosamine generally reflects the state of glycemic control for only the preceding 1 2 weeks Reductions in serum albumin (eg, nephrotic state or hepatic disease) will lower the serum fructosamine value When abnormal hemoglobins or hemolytic states affect the interpretation of glycohemoglobin or when a narrower time frame is required, such as for ascertaining glycemic control at the time of conception in a diabetic woman who has recently become pregnant, serum fructosamine assays offer some advantage Normal values vary in relation to the serum albumin concentration and are 15 24 mmol/L when the serum albumin level is 5 g/dL d Self-monitoring of blood glucose Capillary blood glucose measurements performed by patients themselves, as outpatients, are extremely useful In type 1 patients in whom tight metabolic control is attempted, they are indispensable There are several paper strip (glucose oxidase, glucose dehydrogenase, or hexokinase) methods for measuring glucose on capillary blood samples A reflectance photometer or an amperometric system is then used to measure the reaction that takes place on the reagent strip A large number of blood glucose meters are now available All are accurate, but they vary with regard to speed, convenience, size of blood samples required, and cost Popular models include those manufactured by LifeScan (One Touch), Bayer Corporation (Ascencia), Roche Diagnostics (Accu-Chek), Abbott Laboratories (Precision, FreeStyle), and Home Diagnostics (Prestige) These blood glucose meters are relatively inexpensive, ranging from $50 to $100 each Test strips remain a major expense, costing $50 to$75 apiece Each glucose meter comes with a lancet device and disposable 26- to 33-gauge lancets Some meters have been approved for measuring glucose in blood samples obtained at alternative sites such as the forearm and thigh There is, however, a 5- to 20-minute lag in the glucose response on the arm with respect to the glucose response on the finger Forearm blood glucose measurements could therefore result in a delay in detection of rapidly developing hypoglycemia.



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hemoglobin A1 The remaining HbA1 species contain fructose1,6 diphosphate (HbA1a1); glucose-6-phosphate (HbA1a2); and unknown carbohydrate moiety (HbA1b) The hemoglobin A1c fraction is abnormally elevated in diabetic persons with chronic hyperglycemia Methods for measuring HbA1c include electrophoresis, cation-exchange chromatography, boronate affinity chromatography, and immunoassays Office-based immunoassays using capillary blood give a result in about 9 minutes and this allows for immediate feedback to the patients regarding their glycemic control Since glycohemoglobins circulate within red blood cells whose life span lasts up to 120 days, they generally reflect the state of glycemia over the preceding 8 12 weeks, thereby providing an improved method of assessing diabetic control The HbA1c value, however, is weighted to more recent glucose levels (previous month) and this explains why significant changes in HbA1c are observed with short-term (1 month) changes in mean plasma glucose levels Measurements should be made in patients with either type of diabetes mellitus at 3to 4-month intervals so that adjustments in therapy can be made if HbA1c is either subnormal or if it is more than 2% above the upper limits of normal for a particular laboratory In patients monitoring their own blood glucose levels, HbA1c values provide a valuable check on the accuracy of monitoring In patients who do not monitor their own blood glucose levels, HbA1c values are essential for adjusting therapy Data from the Diabetes Control and Complications Trial (DCCT) showed that there is a linear relationship between the HbA1c and the mean of seven-point capillary blood glucose profiles (preprandial, postprandial, and bedtime) Thus, mean plasma glucose levels of 170, 205, 240, and 275 mg/dL approximately correlate with HbA1c values of 7%, 8%, 9%, and 10%, respectively Use of HbA1c for screening is controversial Sensitivity in detecting known diabetes cases by HbA1c measurements is only 85%, indicating that diabetes cannot be excluded by a normal value On the other hand, elevated HbA1c assays are fairly specific (91%) in identifying the presence of diabetes The accuracy of HbA1c values can be affected by hemoglobin variants or derivatives; the effect depends on the specific hemoglobin variant or derivative and the specific assay used.

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Burns are classified by extent, depth, patient age, and associated illness or injury Accurate estimation of burn size and depth will determine the adequacy of resuscitation

SOLUTION Since the transmission lines are lossless in this power system, the full voltage generated by G1 will be present at each of the loads (a) Since this load is Y-connected, the phase voltage is

The rule of nines (Figure 37 2) is useful for rapidly assessing the extent of a burn More detailed charts based on age are available when the patient reaches the burn unit Therefore, it is important to view the entire patient after cleaning soot to make an accurate assessment, both initially and on subsequent examinations Only second- and third-degree burns are included in calculating the total burn surface area, since first-degree burns usually do not

The survival from major burn injury has dramatically increased in the last 20 years Consistently, the three major risk factors for mortality were age greater than 60 years, burn area greater than 40% of total body surface area, and inhalation injury A good rule of thumb for predicting mortality after severe burn injury is still the Baux Score (age + percent burn, eg, age 50 years + 20% burn = 70% mortality), although this is obviously quite variable depending on associated medical factors Burn size, age, history of electrical injury, history of concomitant trauma (especially penetrating) and female sex as well as duration of stay in the ICU and the presence of mechanical ventilation presage a poorer outcome In ICU patients, low tidal volume ventilation improves ventilationperfusion mismatch and aggressive diagnosis of pneumonia facilitates targeted antibiotic therapy

Your router uses the combination of the destination LAN IP and subnet mask to see if a packet matches that route For example, if you had a packet with the destination 10121426 coming into the router, the router would check the network ID and subnet mask It would quickly determine that the packet matches the first route shown in Figure 8-7 The other two columns in the routing table then tell the router what to do with the packet

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