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non-speci c degenerative lesions including focal or diffuse cellular necrosis, the presence of hyaline inclusion bodies and increased apoptosis Finally, a third group of lesions comprises storage conditions and in ammatory changes This nal group is regarded as the least signi cant in terms of relevance as indicators of contaminant exposure, and provides more information on the general health status and condition of the sh There are some indications that macrophage aggregates in liver relate to environmental contamination, speci cally BKME from pulp and paper mills (Couillard & Hodson, 1996) Without doubt, analysis of gross and microscopic liver lesions provides a sensitive technique for the evaluation of contaminant exposure Ultrastructural changes including abnormalities of the lysosomal system and endoplasmic reticulum as well as proliferation of peroxisomes also appear to be good indicators of contaminant exposure (K hler, 1990a; Braunbeck & V lkl, 1991; K hler et al, 1992).



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As you adjust the settings in Camera Raw, keep in mind that they can be used on more than just the image you are adjusting. You can save them as presets and use Bridge to apply them to other images. You also can apply them to other images within Camera Raw. Open the Preset panel by clicking the Preset tab. Just like the Snapshot panel, the Preset panel is pretty bare until you add your own presets to it. Click the Add New Preset icon on the bottom of the Preset panel. The dialog box shown in Figure 7.12 opens, giving you the option to choose which settings will be saved in the new preset. You also can name your preset so you can find it easily.





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This section presents the basic elements of nuclear steam generation. The section begins with a description of the reaction process and then outlines the process of converting reaction energy to steam. Refueling of nuclear reactors is a process that affects the operations and economics of the plant; accordingly, the refueling cycle and procedure are presented. Safety precautions peculiar to nuclear generation are also presented. Nuclear Energy There are two categories of nuclear energy, fusion and ssion. Fusion is the process of converting atoms of one type into another by fusing their nuclei. The energy state of the fused atoms is lower than the energy state of the original atoms. A common fusion process in the sun is the fusion of two hydrogen atoms to form a helium atom. The differential in energy states is released as radiation. It is hoped that this energy

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However, the presence of liver pathology can only provide evidence of previous exposure The development of lesions may take months (or years) depending on factors as yet not fully understood It is therefore important to collect age data from individuals exhibiting gross hepatic lesions, from those sampled for routine histopathological analysis and also from subsets of the population sampled This data is essential in order to determine relationships between the occurrence of different lesion categories in the same species and of the age distribution of sh exhibiting toxicopathic lesions in the general population There is also a continuing research need for the development of more sensitive techniques to detect changes in the enzyme activities and of DNA damage in hepatocytes as well as ultrastructural changes (Myers et al, 1998a; Winzer & K hler, 1998).

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The application of these techniques in conjunction with histopathological analyses is important in order to determine the relationships between the expression of marker enzymes, adduct formation and the presence of microscopic and gross lesions However, it must be noted that these relationships may differ between sh species (Hus y et al, 1996) 4342 Spleen This organ is of major importance in haematopoiesis and antigen trapping Macrophages remove particulate material from the ellipsoids to the melanomacrophage centres (MMC) Several workers have advocated the use of these structures as biomarkers for exposure to xenobiotics (Bucke et al, 1984; Kranz, 1989; Bucke et al, 1992; Khan et al, 1994; Khan, 1995) It is well recognised that MMCs vary both in number and size between sh species and individuals within a species.

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