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In general terms, they may at best provide an overall assessment of general health status based on the current state of knowledge (Wolke et al, 1981; Blazer et al, 1987; Wolke, 1992) However, the very fact that MMCs can be formed relatively rapidly following a wide variety of environmental and biological insults can be of bene t for the detection of adverse environmental change (Bucke & Dixon, 1992) In addition, the function of MMCs as storage units for unwanted materials which have not been excreted by other means can be exploited for the assessment of contamination by heavy metals since these become trapped in these centres X-ray microanalysis can be used for the speci c localisation and quanti cation of such deposits (Pulsford et al, 1992) Histological and ultrastructural indicators of contaminant exposure are also well expressed in the spleenic tissues Spazier et al.



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The larvae of most, and the eggs of some, marine sh species are planktonic and will thus be exposed to xenobiotics in the water or the surface microlayer (Hardy et al., 1987). There are observations of aberrations in larval development of commercial sh species from both European and American coastal waters (see reviews by von Westernhagen et al., 1988; Longwell et al., 1992; Dethlefsen et al., 1996). Fish larvae may be exposed to xenobiotics while still in the egg, through water after hatching, from yolk or from food consumed during larval development. In addition, mutagenic effects in eggs could also be expressed during larval development. In studies from the North Sea there are indications that xenobiotic exposure through yolk may be at least part of the reason for the observed effects (von Westernhagen et al., 1987, 1989). Larval aberrations may also derive from natural factors, however, including poor quality of eggs, low food reserves in the embryo, and predation, as well as hostile environmental conditions such as physical disturbance, low dissolved oxygen and variable salinity (see Rosenthal & Alderdice (1976), Wiegand et al. (1989) and Purceli et al. (1990) ). Observations from the North Sea suggest that higher water temperature may increase the number of deformed larvae (Dethlefsen et al., 1996). In addition, it is known that survival of larvae (and presumably development) will be affected by food availability immediately after the yolk sac stage. There are two established situations of high larval mortality: the M74 syndrome in the Baltic and the EMS syndrome in the North American Great Lakes. In both syndromes, xenobiotics may contribute to reduced larval survival, but no clear link has been established (see section 4.6).





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The DC is defined as follows: A distributed component (DC) is a design pattern for an autonomous software artifact that can be deployed as a pluggable binary component into a run-time component execution environment . This design pattern is aimed at supporting highproductivity development for large-scale distributed systems . It is normally implemented using a commercially available component implementation technology. When a DC is implemented, the resulting software component is called a distributed component implementation . However, the term DC is normally used for both the design pattern and the implementation, unless the context requires a distinction to be made . The component execution environment is defined as follows: A component execution environment (CEE) is the run-time "socket" into which a distributed component plugs and within which it executes . The CEE consists of a defined set of services, facilities, and middleware, and it is the run-time part of the business component virtual machine . The business component virtual machine (BCVM) is an implementation of the technical architecture . The technical architecture defines how, at all phases of development, technical complexities are hidden from the functional devel-

(1992) provided clear evidence of ultrastructural pathology in.

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Some companies package processors, instructions, processor removal tools, fans, BIOS upgrade utilities, and performance monitoring software together in a kit at reasonable prices. If you are new to processor upgrades, I recommend that you either visit your local computer supply store or contact one online and use an upgrade kit at least for the first few times you do a processor upgrade.

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This case clearly illustrates the diagnostic conundrum that gynecologists encounter. Faced with clinical signs of in ammation, our immediate instinct is to perform a biopsy from representative areas in order to appropriately rule out premalignant and malignant processes. In evaluation of vulvar dermatoses, biopsies serves not only to eliminate the possibility of premalignant processes, but the histologic features of the biopsies are useful in arriving at a clinicopathologic diagnosis.11 Unfortunately, most of us (as gynecologists) are not trained in dermatopathology and in fact have limited knowledge of how to go about arriving at a clinicopathologic interpretation of the histology and the presenting signs and symptoms. In this case, biopsy showed bandlike plasma cell in ltrate in the upper dermis, and in conjunction with ndings of moist erythema con ned to the inner labial fold, the diagnosis of plasma cell vulvitis was rendered. Close collaboration and guidance from our colleagues in dermatopathology (pathologists with specialized training in dermatoses) are

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