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That is, one would use ANCOVA or another method to search for moderators of treatment effectiveness, where the potential moderating variables may consist of client characteristics, attributes of different sites where the program is administered, and aspects of the service delivery The exploratory use of familiar techniques such as regression and ANCOVA may be the easiest approach to the rst phase of principled discovery, but many other possibilities exist In a second technique for discovery, the exploratory data analyses of Tukey (1977; see also Behrens, 1997) can be used to discover possible moderators of program effects and, therefore, to guide informed speculation about underlying mechanisms Even if not predicted in advance, the observation that larger effects cluster in one subgroup or in one setting should set off additional investigation and the search for the underlying mechanism that could account for the observed pattern of effects.

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A third (and conceptually related) method of discovery involves inspecting residuals from the original a priori hypothesis (eg, the treatment control group comparison) Based on the residuals, one may be able to identify sites or cases that have larger or smaller outcomes than would be expected from standard predictors These extreme cases can be contrasted to see whether the variation in outcome appears to be associated with differences in types of.

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Figure 15.7. Zonated features along the sinusoid. The metabolic activity of hepatocytes along the liver sinusoid creates oxygen and hormone gradients from the periportal region to the perivenous. As a result, metabolic and detoxi cation functions are regionally dominant to one zone or the other, as indicated. Some speci c zonated markers are listed under each process. Abbreviations: HA, hepatic artery; PV, portal vein; CV, central vein; PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; FBPase, fructose-1,6-bisphosphatase; GK, glucokinase; PK, pyruvate kinase; CYP, cytochrome P-450. From Allen and Bhatia [2003], adapted from Kietzmann and Jungermann [1997].

where n is the number of input data and s1, s2, . . . , sn, j = [1, n] determine the scalar dispersion in each direction. To increase the functionality of the function f, we propose to use the Mahalanobis distance in the Gaussian function. This type function is also known as the radial basis function (RBF), and it is defined as follows: F(X C) = 1 (2 )

(c) (Weak law of large numbers) Let Z1 , Z2 , . . . , Zn be a sequence of i.i.d. random variables with mean and variance 2 . Let Zn =

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a corollary, evidence regarding diabetes suggests that intensive management yields even better short-term effects and reduces long-term complications beyond those considered to be the norm with conventional diabetes management (see Ruggiero & Javorsky, 1999) Considerable evidence suggests that adolescence is associated with poorer compliance than childhood (Manne, 1998) For example, compared with children, diabetics ages 16 to 19 years administer their injections less regularly, exercise less frequently, eat too few carbohydrates and too many fats, eat less frequently, and test their glucose levels less often (Delameter et al, 1989; Johnson, Freund, Silverstein, Hansen, & Malone, 1990) The average age when children rst show a pattern of serious and persistent noncompliance with diabetes management is 148 years (Kovacs, Goldston, Obrosky, & Iyengar, 1992).

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Fano s inequality the data-processing inequality the chain rule the fact that Yi depends only on X1i and X2i and is independent of everything else the chain rule and removing conditioning

heterogeneous patient groups that may have encompassed subjects manifesting purely psychiatric disorders Considerable data indicates that cognitive behavioral interventions are very effective for individuals with depression; therefore, it remains unclear as to which population or subgroups of patients actually bene t from this type of treatment Medical Utilization Because most prior research has consisted of medically referred samples, it has been unclear what medical services have been used by the population of individuals with CFS and what proportion of individuals suffering from CFS have gone untreated or have been treated for other illnesses In a study of individuals with chronic fatigue, CFS, and bromyalgia from a university-based chronic fatigue clinic (Bombardier & Buchwald, 1996), individuals were found to access health care services, both allopathic and alternative, at a rate higher than the average, possibly indicating simultaneous and uncoordinated use of services.

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