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When AIDS was first recognized in the United States in 1981, cases were identified by finding severe opportunistic infections such as Pneumocystis pneumonia that indicated profound defects in cellular immunity in the absence of other causes of immunodeficiency When the syndrome was found to be caused by HIV, it became obvious that severe opportunistic infections and unusual neoplasms were at one end of a spectrum of disease, while healthy seropositive individuals were at the other end The Centers for Disease Control and Prevention (CDC) AIDS case definition (Table 31 1) includes opportunistic infections and malignancies that rarely occur in the absence of severe immunodeficiency (eg, Pneumocystis pneumonia, central nervous system lymphoma) It also classifies persons as having AIDS if they have positive HIV serology and certain infections and malignancies that can occur in immunocompetent hosts but that are more common among persons infected with HIV (pulmonary tuberculosis, invasive cervical cancer) Several nonspecific conditions, including dementia and wasting (documented weight loss) in the presence of a positive HIV serology are considered AIDS The definition includes criteria for both definitive and presumptive diagnoses of certain infections and malignancies Finally, persons with positive HIV serology who have ever had a CD4 lympho-



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jQuery cannot (because JavaScript cannot) create a PDF from data, no...it can get one from your server (like any other request), but it cannot ...

The ongoing demand for bandwidth on the Internet means that the networking industry is continually reaching for faster LAN speeds 10-Gigabit Ethernet (10 GbE) is showing up in high-level LANs, with the anticipation of trickle down to the desktops in the near future NOTE There are proposed Ethernet standards that go way beyond 10-Gbps speeds, including a 100 GbE proposal, but nothing is fully standardized as of this writing 10 GbE is the reigning king of network speeds Because 10 GbE is still a new technology, there are a large number of standards in existence Over time many of these standards will certainly grow in popularity and some will disappear For now, though, the landscape is in flux 10 GbE has a number of fiber standards and two copper standards 10 GbE was first and foremost designed with fiber optics in mind As a result, it has only been since 2008 that 10-GbE copper products have actually (and very expensively) began to appear for sale

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cyte count below 200 cells/mcL or a CD4 lymphocyte percentage below 14% are considered to have AIDS Inclusion of persons with low CD4 counts as AIDS cases reflects the recognition that immunodeficiency is the defining characteristic of AIDS The choice of a cutoff point at 200 cells/mcL is supported by several cohort studies showing that AIDS will develop within 3 years in over 80% of persons with counts below this level in the absence of effective antiretroviral therapy The 1993 definition was also expanded to include persons with positive HIV serology and pulmonary tuberculosis, recurrent pneumonia, and invasive cervical cancer The prognosis of persons with HIV/AIDS has dramatically improved due to the introduction of highly active antiretroviral therapy (HAART) in the mid 1990s One consequence is that fewer persons with HIV ever develop an infection or malignancy or have a low enough CD4 count to classify them as having AIDS, which means that the CDC definition has become a less useful measure of the impact of HIV/AIDS in the United States Conversely, persons in whom AIDS had been diagnosed based on a serious opportunistic infection, malignancy, or immunodeficiency may now be markedly healthier, with high CD4 counts, due to the use of HAART Therefore, the Social Security Administration as well as most social service agencies focus on functional assessment for determining eligibility for benefits rather than the simple presence or absence of an AIDS-defined illness Clinicians with limited experience in HIV/AIDS should refer HIV-infected patients to specialists with experience, given the increasing number and complexity of treatment regimens available Extra efforts should be made to obtain specialty consultation for those patients not responding to their current regimens; those intolerant of standard antiviral drugs; those in need of systemic chemotherapy; and those with complicated opportunistic infections, particularly when invasive procedures or experimental therapies are needed Resources are available to help clinicians care for HIVinfected persons Clinicians should call their state medical associations for a list of local resources.

The modes of transmission of HIV are similar to those of hepatitis B, in particular with respect to sexual, parenteral, and

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