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Fresh-frozen plasma is available in units of approximately 200 mL Fresh plasma contains normal levels of all coagulation factors (about 1 unit/mL) Fresh frozen plasma is used to correct coagulation factor deficiencies and to treat TTP The risk of transmitting viral disease is comparable to that associated with transfusion of red blood cells Cryoprecipitate is made from fresh plasma One unit has a volume of approximately 20 mL and contains approximately 250 mg of fibrinogen and between 80 and 100 units of factor VIII and vWF Cryoprecipitate is used to supplement fibrinogen in cases of congenital deficiency of fibrinogen or DIC One unit of cryoprecipitate will raise the fibrinogen level by about 8 mg/dL



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Dyspepsia refers to acute, chronic, or recurrent pain or discomfort centered in the upper abdomen The discomfort may be characterized by or associated with upper abdominal fullness, early satiety, burning, bloating, belching, nausea, retching, or vomiting Heartburn (retrosternal burning) should be distinguished from dyspepsia Patients with dyspepsia often have heartburn as an additional symptom When heartburn is the dominant complaint, gastroesophageal reflux is nearly always present Dyspepsia occurs in 25% of the adult population and accounts for 3% of general medical office visits

The prevalence of H pylori-associated chronic gastritis in patients with dyspepsia without peptic ulcer disease is 20 50%, the same as in the general population





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Figure P13-2 One-line diagram of the power system in Problem 13-8 SOLUTION To simplify this problem, we will pick the base quantities for this power system to be 100 MVA and 138 kV at generator G1 , which is in Region 1 Therefore, the base quantities are:

The abrupt onset of epigastric or right upper quadrant pain due to cholelithiasis or choledocholithiasis should be readily distinguished from dyspepsia

Diabetes, thyroid disease, renal insufficiency, myocardial ischemia, intra-abdominal malignancy, gastric volvulus or paraesophageal hernia, and pregnancy are sometimes accompanied by dyspepsia

Acute, self-limited indigestion may be caused by overeating, eating too quickly, eating high-fat foods, eating during stressful situations, or drinking too much alcohol or coffee Many medications cause dyspepsia, including aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides), various diabetes drugs (metformin, alpha-glucosidase inhibitors, amylin analogs, GLP-1 receptor antagonists), cholinesterase inhibitors (donepezil, rivastigmine), corticosteroids, digoxin, iron, and opioids

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This is the most common cause of chronic dyspepsia Up to two-thirds of patients have no obvious organic cause for their symptoms after evaluation Symptoms may arise from a complex interaction of increased visceral afferent sensitivity, gastric delayed emptying or impaired accommodation to food, or psychosocial stressors Although benign, these symptoms may be chronic and difficult to treat

Peptic ulcer disease is present in 5 15% of patients with dyspepsia Gastroesophageal reflux disease is present in up to 20% of patients with dyspepsia, even without significant heartburn Gastric cancer is identified in 1% but is rare in persons under age 45 years Other causes include gastroparesis (especially in diabetes mellitus), lactose intolerance or malabsorptive conditions, and parasitic infection (Giardia, Strongyloides)

Given the nonspecific nature of dyspeptic symptoms, the history has limited diagnostic utility It should clarify the chronicity, location, and quality of the discomfort, its relationship to meals, and whether it is relieved by antacids Concomitant weight loss, persistent vomiting, constant or severe pain, dysphagia, hematemesis, or melena warrants endoscopy or abdominal imaging Potentially offending medications and excessive alcohol use should be identified and discontinued if possible The patient s reason for seeking care should be determined Recent changes in employment, marital discord, physical and sexual abuse,

100, 000, 000 VA = 4184 A 3 (13,800 V )

Although chronic gastric infection with H pylori is an important cause of peptic ulcer disease, it is an uncommon cause of dyspepsia in the absence of peptic ulcer disease

tinuation of the proton pump inhibitor should be tested for H pylori and treated if positive Endoscopic evaluation is warranted when symptoms fail to respond to initial empiric management strategies or frequent symptom relapse occurs after discontinuation of antisecretory therapy Abdominal imaging (ultrasonography or CT scanning) is performed only when pancreatic or biliary tract disease is suspected Gastric emptying studies are valuable only in patients with recurrent vomiting Ambulatory esophageal pH testing may be of value when atypical gastroesophageal reflux is suspected

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