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Importantly, a synergistic effect against a VISA strain was noted for the combination of MV-L and vancomycin Interestingly, unlike lysostaphin, MV-L did not display activity against S epidermidis The inability of MV-L to kill S epidermidis may prove advantageous because this species can inhibit the growth of S aureus In a murine model of nasal colonization, one topical dose of lysin administered to mice 60 h after intranasal MRSA inoculation completely cleared bacteria in one of nine mice and substantially reduced the colonization in the remaining eight animals In a murine model of MRSA bacteremia, injection of a single dose of MV-L 60 min after a lethal dose of MRSA reduced the mortality rate to 40%, whereas administration of the enzyme either simultaneously with or 30 min after MRSA rescued 100% of the mice Another anti-staphylococcal lytic enzyme is lysin encoded by S aureus 11 bacteriophage (Navarre et al.



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The California design rst set an unconstrained price across the entire system The resulting dispatch was not feasible and contributed to congestion problems While the California approach was inferior from an operational approach, designers believed that it would provide a more competitive bidding process Their line of reasoning was as follows Because actual grid constraints limit a producer s ability to supply power, imposing the grid constraints limits competition and leads to a higher market clearing price Conversely, by setting an unconstrained bidding pool, competition is enhanced because all producers compete in the unconstrained market While competitive bidding is desirable, it cannot be achieved by pretending that transmission constraints don t exist California s system did not result in more competitive bidding The grid constraints were well known by all market participants.





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Freedom of Speech and Assembly The First Amendment prohibits the government from interfering with the rights of free speech and assembly and freedom of religious choice In Tinker and subsequent cases, the courts generally have acknowledged the right of students to free speech and assembly, as long as the exercise of those rights does not significantly interfere with or disrupt the functioning of the school Freedom of speech and assembly can be restricted when their exercise materially and substantially interferes with schooling The right to free speech does not protect the use of obscene language, gestures, or materials (see Fischer & Sorenson, 1996) Privacy Rights No right to privacy is mentioned expressly in the Constitution.

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1999; Donovan et al 2006a) This enzyme is composed of an N-terminal CHAP domain, an amidase domain, and a C-terminal cell wall-binding SH3b domain, all of which are required for maximal lytic activity Deletion of either enzymatic domain decreased the ef ciency of bacterial lysis, whereas deletion of the cell wall-binding domain practically abolished the antibacterial activity of the enzyme 11 lysin was also found to be capable of eliminating the bio lm of S aureus, but not that of S epidermidis, on arti cial surfaces (Sass and Bierbaum 2007) The effects of 11 against both staphylococcal cells and S aureus bio lm were essentially comparable to those of lysostaphin In the turbidity reduction assay, the antibacterial range of the lysin was shown to encompass several major staphylococcal mastitis pathogens, including both S aureus and.

Some took advantage of the constraints to earn higher revenues by employing tactics that are described in the previous section The bidding process also differed in that generators in PJM bid in their operating parameters while generators in the California market bid in a price by hour and volume The price bidding in the California markets provided a simple method for the CALPX to match load and production bidding However, it was problematic for producers because production quantities and costs could only be estimated..

A number of different privacy rights have been carved out of the First Amendment concept of liberty, Fifth Amendment protections against self-incrimination, Ninth Amendment reservation of rights to the people, and the Fourth Amendment prohibition against unreasonable search and seizure (Hummel, Talbutt, & Alexander, 1985) In a case that received considerable attention from legal scholars, a federal district court ruled that parents of school children have a right to be free from the invasion of family privacy by the school (Merriken v Cressman, 1973; see 10) This right to privacy was recognized only for the parents or family unit; the courts generally have not recognized an independent student right to privacy in the schools However, federal education law (eg, the Family Educational Rights and Privacy Act discussed later in this chapter) now provides some guidance regarding protection of the privacy rights of pupils and their parents..

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