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The potential health outcomes of immunological changes that follow psychological interventions remain to be determined Further studies are needed that more directly assess changes in disease incidence, severity, and duration, as well as studies that include immune measures in therapy outcome studies Finally, in evaluating psychological intervention studies, it is important to remember that it may not be possible or desirable to enhance immune function (eg, autoimmune disease) if the immune system is already functioning at normal levels There is greater likelihood of positive intervention effects when participants show some degree of dysregulation in immune function relative to their demographically matched peers Health impact will likely depend on the type, intensity, and duration of intervention, the extent and duration of immune alteration, and prior immunological and health status (Kiecolt-Glaser & Glaser, 1992).



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36 = 2(i,

(A. 103)





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including 210 isolates obtained from nasal swabs of S. aureus carriers and 219 isolates from blood of individuals with S. aureus bacteremia (von Eiff et al. 2003). No differences were found in the susceptibilities of the MSSA and MRSA isolates to lysostaphin, and the MBC values for 10 selected strains were 0.16 g/ml. Aside from planktonic cells, staphylococcal bio lms can also be eliminated by lysostaphin. This effect is speci c to bio lms formed by lysostaphin-sensitive staphylococci (MSSA, MRSA, and Staphylococcus epidermidis). Lysostaphin s activity against staphylococcal bio lms was shown to be more potent than those of oxacillin, vancomycin, and clindamycin (Wu et al. 2003). A very important problem is the development of an assay that could be used to determine the susceptibility of staphylococci to lysostaphin. This question was addressed in a study, in which four different methods for distinguishing lysostaphin-sensitive strains from lysostaphin-resistant ones were compared (MIC, MBC, turbidity, and disk diffusion assays) (Kusuma and Kokai-Kun 2005). The study was performed on 57 different S. aureus strains, including MSSA, MRSA, VISA, and mupirocin-resistant strains, and de ned genetic mutants of S. aureus. As negative controls, three reference lysostaphin-resistant S. aureus strains were included. Although some inconsistencies were noted between individual assays when determining the degree of lysostaphin susceptibility, there was a high correlation between all four methods with respect to identifying lysostaphin-susceptible bacteria (all of the 57 strains examined were susceptible to lysostaphin by all four methods, whereas all reference strains were resistant). This study revealed that the simplest and most reproducible assay to determine lysostaphin susceptibility is the disk diffusion assay.

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Potential bene ts of psychological interventions on immunity may be particularly relevant for wound healing and surgical recovery In particular, interventions that target fear and distress before surgery and pain management following surgery may improve postoperative outcomes and recovery through modulation of endocrine and immune systems (Kiecolt-Glaser, Page, Marucha, MacCallum, & Glaser, 1998)..

that estimates d ( i ) = s(i - A) optimally in the least-mean-squares sense, where the { - b ( i ) } denote the coefficients of the feedback filter while the {f(i)}denote the coefficients of the forward filter. This application coincides with the one described in Sec. 6.4, except that now, in conformity with the notation of this chapter, we are denoting the input to the equalizer by u ( i ) and the symbol to be estimated by d ( i ) . We are also relying on the formulation of the decision-feedback equalizer as a linear estimation problem (cf. Eq. (6.35)). Clearly, the equalizer wothat solves min E Id(i) - utwlz is

(c) Assume Inf(i)l < 1foralliandm,anddefinethenormalizederrorsb $ ( i ) = b f f l ( i ) / < g 2 ( i ) and f$(i) = f,(i)/& (i). Show that the normalized errors satisfy the recursions:

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