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Dagher (2001) used a dopamine receptor ligand ([C]raclopride) to detect changes in extracellular dopamine after 30 min of rTMS over the left dorsolateral frontal lobe or over the left occipital lobe The dopamine receptor ligand was injected within 5 min of completion of the rTMS trial, and PET imaging took place within 30 min The study found decreased dopamine uptake in the ipsilateral caudate following left frontal TMS, with no effects seen in the putamen, nucleus accumbens, or contralateral caudate Findings from such combined TMS and PET studies can have important implications for the cognitive neuroscientist neuropsychologist during experimental design of TMS studies First, the effects of TMS may extend well beyond the immediate hot spot that was focally stimulated, and this consideration may play a role in the design of control tasks.



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The ip side of this is that rTMS may be used as a powerful tool for studying local cortical reactivity and functional connectivity (Bailey, Karhu, & Ilmoniumi, 2001; Pascual-Leone, Walsh, & Rothwell, 2000) Finally, although the effects of TMS may be relatively short lasting in many conditions, the temporal course and dissipation of shorter and longer lasting effects (eg, in treatment of depression) has not been carefully studied Methodological Issues How does one go about designing a TMS study What important methodological problems must be addressed Some issues depend on whether TMS or rTMS is being conducted and how the stimulation parameters temporally relate to the particular neurocognitive task under study (eg, naming, a working memory n-back task, or a motor sequencing task) In rTMS studies, decisions must be made about various stimulation parameters.





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These include (a) the frequency (in Hz) of TMS stimuli, (b) the duration of the train of stimulation, (c) the interval between trains, (d) the total number of trains, (d) the intensity of the stimulation, and (e) the total number of stimuli in a given session, or to a speci c brain region For example, consider the study that involves 50 2-s trains of 40 stimuli delivered at a rate of 20 Hz with an intertrain interval of 28 s In this study, a subject would receive 2 s of rTMS (40 stimuli) that is delivered every 30 s for 25 min, resulting in 2,000 total stimuli These various stimulation parameters for rTMS are guided in part by safety considerations For both TMS and rTMS, intensity of magnetic stimulation is individually determined Typically, intensity of stimulation is based on the individual s motor-evoked threshold (eg.

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, intensity = 70% motor-evoked potentials; MEP, or 120% MEP) This can be quanti ed by attaching surface EMG electrodes over the abductor policis brevis muscles in the hand.

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Notice that the procedure starts with the keyword Function, rather than Sub, followed by the name of the function (Reverse). This custom function uses only one argument (InString), enclosed in parentheses. As String defines the data type of the function s return value. (Excel uses the variant data type if none is specified.) The second line is simply a comment (optional) that describes what the function does. This is followed by a Dim statement for the two variables (i and StringLength) used in the procedure. Then the procedure initializes the result as an empty string. Note that I use the function s name as a variable here. When a function ends, it always returns the current value of the variable that corresponds to the function s name. Next, VBA s Len function determines the length of the input string and assigns this value to the StringLength variable. The next three instructions make up a For-Next loop. The procedure loops through each character in the input (backwards) and builds the string. Notice that the Step value in the For-Next loop is a negative number, causing the looping to proceed in reverse. The instruction within the loop uses VBA s Mid function to return a single character from the input string. When the loop is finished, Reverse consists of the input string, with the characters rearranged in reverse order. This string is the value that the function returns. The procedure ends with an End Function statement.

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