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, Recent Development of the Neutral Theory Viewed from the Wrightian Tradition of Theoretical Population Genetics, Proc Natl Acad Sci USA, 88, 5969 5973 (1991) Kruglyak, L, Prospects for Whole-Genome Linkage Disequilibrium Mapping of Common Disease Genes, Nat Genet, 22, 139 144 (1999) Prichard, BN, et al, New Approaches to the Uses of Beta Blocking Drugs in Hypertension, J H Hypertens, 14(Suppl 1), S63 S68 (2000) Roychoudhury, AK, and M Nei, Human Polymorphic Genes: World Wide Distribution, Oxford University Press, New York, pp 3 18 (1988) Sham, P, Shifting Paradigms in Gene-Mapping Methodology for Complex Traits, Pharmacogenomics, 2, 195 202 (2001) Shriver, MD, et al, Ethnic-Af liation Estimation by Use of Population-Speci c DNA Markers, Am J Hum Genet, 60, 957 964 (1997) Smith, MW, et al.

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compare Section 6.3. Now minimize I c ( F ) ;the variational conditions imply that -4& /fi = constonthesetwherefo(X) > ( l - - ~ ) ( p ( ~ ) , a n d t h a t ~ ~ , ,= 0. ) (+c This yields (4.84) - (4.87), and it only remains to check that this indeed is a solution. For details, see Collins (1976). Exhibit 4.10 shows some of the quantitative aspects. The last column gives the maximal risk l / I c ( F o ) .Clearly, a choice c 2 5 will increase it only by a negligible amount beyond its minimax value (c = m), but a choice c 5 3 may have quite poor consequences. In other words it appears that redescending +-functions are much more sensitive to wrong scaling than monotone ones.

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the quantum ef ciency as function of energy is presented in Figure 4.1.14). The low energy tail in the spectrum (p/V ratio) and the drop in quantum ef ciency at low energy is due to partial charge collection of photons converting in or near the entrance window. This drop is still much lower than in other (MOS) CCDs. The loss at high energy is due to the limited thickness of the silicon wafer. Figure 4.1.14 also indicates the improvement achievable by increasing the sensitive thickness to 500 m. As the bias voltage required for depletion grows with the square of the thickness but only linearly with doping density (Equation 4.1.1) the maximum depletable thickness achievable thickness at reasonable bias is limited. As an example, 4.5 k cm n-type silicon (ND = 1012 donors per cm3 ) and a bias voltage of 500 V result in a depletion depth of 800 m. Important aspects on the subject of energy resolution were also treated in Sections 4.1.4 and 4.1.6 and for drift detectors in Section 4.1.9. These aspects concern electronic noise (Section 4.1.4), ionization statistics (Section 4.1.6) and their combined effect (Section 4.1.9). Those results apply also to CCDs. According to Figure 4.1.45, the

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(4.124a)

To select features for filleting, you must select them from the FeatureManager. The Selection Filter only filters edges and faces for fillet selection. You can select loops in two ways: through the right-click Select Loop option, or by selecting a face and Ctrl+selecting an edge on the face. Another option for selecting edges in the Fillet command is the Select Through Faces option, which appears on the Fillet Options panel. This option enables you to select edges that are hidden by the model. This can be a useful option on a part with few hidden edges, or a detrimental option on a part where there are many edges due to patterns, ribs, vents, or existing fillets. You can control a similar option globally for features other than fillets by choosing Tools Options Display/Selection, Allow Selection In HLR [Hidden Lines Removed], and Shaded Modes.n

This panel enables you to set the arrows and dimension lines to be placed inside the witness lines. You can perform this function more easily by using the handles on the arrowheads. From this panel, you can also change the display type of individual arrowheads.

, Markers for Mapping by Admixture Linkage Disequilibrium in African American and Hispanic Populations, Am J Hum Genet, 69, 1080 1094 (2001) Sobel, E, et al, Detection and Integration of Genotyping Errors in Statistical Genetics, Am J Hum Genet, 70, 496 508 (2002)..

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