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One small but highly successful nonprofit decided that it would focus on only one project before developing a more comprehensive technology plan. Realizing that many group members felt hesitant about using computers, it was decided that what was needed most was a resounding success. The project chosen would consist only of creating a simple but accurate database of contributors and potential contributors. However, every single member of the organization would participate. Each was responsible for verifying existing information and for identifying a given number of possible donors. Each attended workshops to learn to use the database and followed written instructions for entering information. It was not until group members felt satisfied that they had a firm grip on the contributors database that they returned to their technology plan and considered future computer development. As might be expected, it was discovered that this was far from the most efficient way of creating a database and errors were not uncommon. However, in the end the project resulted not only in a useful resource but in a group of enthusiastic, computer-literate volunteers as well.



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Find tools for building strong and effective boards from BoardSource at www.boardsource.org. Read the Board Development FAQ at www.allianceonline.org/FAQ/ board_development. Take a look at the Board of Directors FAQ at www.nonprofits.org/ npofaq/keywords/1a.html. Read about Building and Managing a Better Board at www. enterprisefoundation.org/model%20documents/1105-Building& ManagingBetterBoard.pdf. Get the Complete Toolkit for Boards at www.mapnp.org/library/ boards/boards.htm.





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The level of cognitive functioning of individuals with autism spans a broad range, from profound mental retardation to superior intellect (Pickett & London, 2005) Although individuals with ASD evidence a range of ability levels, a large percentage of those identi ed with ASD exhibit impaired cognition (E H Cook & Leventhal, 1995; DiCiccoBloom et al, 2006) Additionally, there is a high rate of co-occurrence with epilepsy (see 10) and attentional disorders, including ADHD (see 6), as well as other externalizing disorders (E H Cook & Leventhal, 1995) Overlap and similarities in behavioral manifestations also have been noted with Tourette syndrome (see 7), particularly in relation to echolalia, perseverations, and stereotypic movements (Canitano & Vivanti, 2007; Geurts et al, 2008) Additional associated features include hypersensitivity to sounds, tactile stimulation, or odors Across studies, there are some indications of dif culty with imitation of motor movements.

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variants are being observed in elderly individuals who are apparently cancer free The availability of the sequence for much of the human genome is a major resource for positional cloning and identi cation of genes responsible for genetic diseases In earlier days (really only 5 years ago), after a gene had been localized to a chromosomal region, it was usually necessary to build genetic and physical maps spanning the regions before focusing on gene identi cation Reading the description of the cloning of the cystic brosis gene provides insight into the impact of the availability of the genomic sequence for much of the human genome (and high-resolution genetic maps described below) on gene identi cation and characterization (Riordan et al, 1985).

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Today, positional cloning efforts can often move rapidly from the mapping stage, which identi es the region of the genome containing the genetic variation (gene) associated with the phenotype or disease, to the stage of analyzing the most interesting candidate genes in the region This can now often be accomplished by harvesting data available in public databases and without the need to build additional genetic maps or isolate and sequence DNA clones spanning a region of interest to identify potential candidate genes The impact of these changes has been described in an article entitled Leaving Kansas Finding Genes in 1997 by Dr Mary-Claire King (King, 1997), which was written before the draft sequence of the human genome was available The genetics, and thus the cloning, of the genes for these disease examples was relatively straightforward.

Motor and movement abnormalities have been identi ed as early as infancy from home videos in some cases, but this is most noticeable in those children who have developmental delays in addition to autism (Ozonoff et al, 2008) Some of the motor dif culties relate to gait, knee exion, and posturing (Damasio & Maurer, 1978; Jansiewicz et al, 2006; Minshew, Sung, Jones, & Furman, 2004; Vilensky, Damasio, & Maurer, 1981) Little research has examined the outcomes of individuals with ASDs, but what research has been done has not been overly optimistic Some of the early research found that 60% to 75% of those with autism had poor outcomes, as de ned by living in institutions and/or not receiving appropriate residential or vocational services (Lotter, 1978).

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