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24 Oct 2017 ... Lets check sample code for generating PDF Add libraries - JQuery and jsPDF < script src="https://code. jquery .com/ jquery -1.12.3.min.js"></scr. It is important to stress to the patient that levothyroxine therapy must be continued long-term and that regular clinical reassessments will be required for life Most patients ultimately require levothyroxine in doses of 75 250 mcg orally daily For most patients with hypothyroidism, a stable maintenance dose can usually be found However, the dosage requirement can rise due to increased hepatic metabolism of thyroxine induced by certain medications: carbamazepine, phenobarbitol, phenytoin, rifabutin, rifampin, and the antitumor drug imatinib (Gleevec) Amiodarone can cause changes in thyroxine dose requirements by various mechanisms Malabsorption of thyroxine can be caused by coadministration of thyroxine with certain medications: raloxifene, antacids, bile acid binding resins, calcium, didanosine, magnesium, and iron salts (including iron found in multivitamins with minerals) Patients who take proton pump inhibitors or in whom atrophic gastritis develops may malabsorb thyroxine, resulting in an increased dosage requirement Different thyroxine formulations do not appear to have the exact same bioavailability Compared with Synthyroid brand of T4 (100%), there have been reports of varying bioavailabilities of different thyroxine preparations: Lannet generic T4 (Unithyroid), 103%; Mylar generic T4, 109%; Sandoz generic T4, 109%; and Levoxyl brand T4, 114% Such differences in bioavailability of different T4 formulations may have a subtle but significant clinical impact It is therefore recommended that patients always continue to take the same brand name of thyroxine or the same manufacturer s generic thyroxine Women with hypothyroidism typically require increased doses of T4 during pregnancy and during therapy with oral estrogen Conversely, T4 dosage requirements for women often decrease with delivery, cessation of oral estrogen, and menopause There is no standardized optimal dose of levothyroxine, so each patient s dose must be based on careful clinical assessment Although serum TSH levels can be helpful in determining optimal dosing, it is important not to rely entirely on this test alone During pregnancy, it is critical to administer adequate levothyroxine to a hypothyroid woman Although the fetal thyroid begins secreting thyroid hormone at about 18 weeks of gestation, fetal thyroid development is not complete until term Maternal T4 crosses the placenta, and the fetus is at least partially dependent upon maternal T4 for central nervous system development particularly in the second trimester Maternal hypothyroidism after the first trimester appears to cause some developmental delay in offspring It is therefore important to carefully monitor women with hypothyroidism during their pregnancies with serum TSH (FT4 concentrations in hypopituitarism) determinations every 4 6 weeks and to increase T4 replacement progressively as required There is considerable individual variation in the requirement for additional T4 replacement during pregnancy For women receiving replacement thyroxine, it is prudent to increase thyroxine dosages by 30% as soon as pregnancy is confirmed. javascript pdf generator utf 8: MrRio/jsPDF: Client-side JavaScript PDF generation for ... - GitHub javascript pdf generator open source Generate PDF from HTML with CSS by using JavaScript and JQuery
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