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companies that could afford their own WAN connections, but what about individuals and small companies that couldn t or wouldn t pay hundreds of dollars a month for a T1 This area, the infamous last mile, was a serious challenge early on for both Internet connections and private connections because the only common medium was POTS lines A number of last-mile solutions have appeared over the years, and the CompTIA Network+ exam tests you on the most popular ones Let s begin with the granddaddy of them all, the telephone line that runs to your house



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Serum ferritin < 12 mcg/L Caused by bleeding in adults unless proved otherwise Responds to iron therapy

Iron deficiency is the most common cause of anemia worldwide The causes are listed in Table 13 3 Aside from circulating red blood cells, the major location of iron in the

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body is the storage pool as ferritin or as hemosiderin and in macrophages The average American diet contains 10 15 mg of iron per day About 10% of this amount is absorbed Absorption occurs in the stomach, duodenum, and upper jejunum Dietary iron present as heme is efficiently absorbed (10 20%) but nonheme iron less so (1 5%), largely because of interference by phosphates, tannins, and other food constituents Small amounts of iron approximately 1 mg/d are normally lost through exfoliation of skin and mucosal cells There is no physiologic mechanism for increasing normal body iron losses Menstrual blood loss in women plays a major role in iron metabolism The average monthly menstrual blood loss is approximately 50 mL, or about 07 mg/d However, menstrual blood loss may be five times the average To maintain adequate iron stores, women with heavy menstrual losses must absorb 3 4 mg of iron from the diet each day This strains the upper limit of what may reasonably be absorbed, and women with menorrhagia of this degree will almost always become iron deficient without iron supplementation In general, iron metabolism is balanced between absorption of 1 mg/d and loss of 1 mg/d Pregnancy may also upset the iron balance, since requirements increase to 2 5 mg of iron per day during pregnancy and lactation Normal dietary iron cannot supply these requirements, and medicinal iron is needed during pregnancy and lactation Repeated pregnancy (especially with breast-feeding) may cause iron deficiency if increased requirements are not met with supplemental medicinal iron Decreased iron absorption can on very rare occasions cause iron deficiency and usually occurs after gastric surgery, though concomitant bleeding is frequent By far the most important cause of iron deficiency anemia is blood loss, especially gastrointestinal blood loss Chronic aspirin use may cause it even without a documented structural lesion Iron deficiency demands a search for a source of gastrointestinal bleeding if other sites of blood loss (menorrhagia, other uterine bleeding, and repeated blood donations) are excluded Chronic hemoglobinuria may lead to iron deficiency since iron is lost in the urine; traumatic hemolysis due to a prosthetic cardiac valve and other causes of intravascular.

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Decreased production Hemoglobin synthesis: iron deficiency, thalassemia, anemia of chronic disease DNA synthesis: megaloblastic anemia Stem cell: aplastic anemia, myeloproliferative leukemia Bone marrow infiltration: carcinoma, lymphoma Pure red cell aplasia Increased destruction Blood loss Hemolysis (intrinsic) Membrane: hereditary spherocytosis, elliptocytosis Hemoglobin: sickle cell, unstable hemoglobin Glycolysis: pyruvate kinase deficiency, etc Oxidation: glucose-6-phosphate dehydrogenase deficiency Hemolysis (extrinsic) Immune: warm antibody, cold antibody Microangiopathic: thrombotic thrombocytopenic purpura, hemolyticuremic syndrome, mechanical cardiac valve, paravalvular leak Infection: clostridial Hypersplenism

Deficient diet Decreased absorption Increased requirements Pregnancy Lactation Blood loss Gastrointestinal Menstrual Blood donation Hemoglobinuria Iron sequestration Pulmonary hemosiderosis

There are many different types of telephone lines available, but all the choices break down into two groups: dedicated and dial-up Dedicated lines are always off the hook (that is, they never hang up on each other) A dedicated line (like a T1) does not have a phone number In essence, the telephone company creates a permanent, hard-wired connection between the two locations, rendering a phone number superfluous Dial-up lines, by contrast, have phone numbers; they must dial each other up to make a connection When they re finished communicating, they hang up Two technologies make up the overwhelming majority of dial-up connections PSTN and ISDN

hemolysis (eg, paroxysmal nocturnal hemoglobinuria) should also be considered Frequent blood donors may also be at risk for iron deficiency

As a rule, the only symptoms of iron deficiency anemia are those of the anemia itself (easy fatigability, tachycardia, palpitations and tachypnea on exertion) Severe deficiency causes skin and mucosal changes, including a smooth tongue, brittle nails, and cheilosis Dysphagia because of the formation of esophageal webs (Plummer Vinson syndrome) also occurs Many iron-deficient patients develop pica, craving for specific foods (ice chips, etc) often not rich in iron

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