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Environmental appraisal: This process examines the potential environmental impacts of the project and identifies measures for mitigating adverse effects These individual elements overlap to a great extent It is the task of the feasibility study to integrate them and to develop a considered recommendation that takes all relevant factors into account The recommendation should include not only a statement of the best option, but also an outline brief describing the purpose of the project, its integration with existing systems, an outline budget and key milestones including a target completion date..

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Substantial amounts of source reduction can often be gained by switching from glass or metal to plastics packaging and by switching from rigid or semirigid packaging to exible packaging (usually containing plastic) While such reduction is usually measured in terms of weight, there is typically a reduction in the volume of packaging material used as well When Clorox switched from glass bottles to plastic bottles for barbeque sauce and salad dressing, the new PET bottles weighed 85% less than the old glass bottles The result was reduction of nearly 30 million pounds of glass per year Use of corrugated boxes was cut by 2 million pounds per year since the plastic bottles used less space [12] For example, 18-oz glass jars for peanut butter weigh 102 oz each PET jars of the same capacity weigh only 17 oz, an 83% reduction..

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Figure 5-5: Page orientation choices are available after selecting the Layout tab in the Print dialog box.

Edge value Edge value, dB A, effective length, coherent gain A, dB C, effective power, incoherent power gain C, dB D (see Section 5.1) G (see Section 5.1) Efficiency g, processing gain Efficiency g, processing gain, dB Noise beamwidth Half-power beamwidth RMS beamwidth RMS aperture First sidelobe, dB Falloff dB/octave Scalloping loss Scalloping loss, dB Worst case loss Worst case loss, dB

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How to edit PDF files: Open a file in Acrobat. Click on the Edit PDF tool in the right pane. Click the text or image you wish to edit. Add or edit text on the page. Add, replace, move, or resize images on the page using selections from the Objects list. Convert PDF to Word · Instantly edit scanned PDFs · Acrobat Reader mobile app

most common is the Prader-Willi syndrome, characterized by insatiable hyperphagia from early childhood, leading to early-onset morbid obesity, accompanied by muscular hypotonia, short stature, hypogonadism and mental retardation (see 21) All these conditions are rare, accounting in total for less than 1% of unselected cases of obesity in adults The prevalence is higher among children, especially those with earlyonset morbid obesity and those referred to specialist centres for investigation and management of obesity (Figure 815) Elucidation of the causes of genetic obesity in rodents has led to the identi cation of several genes that are crucial to energy homeostasis, and mutations in some of the human analogues of these genes have now been shown to cause obesity in humans; reviews of animal models of obesity can be found in West and York (1998) and Speakman et al (2008).

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Several genetic obesity syndromes in rodents are due to mutations affecting leptin and its target neurones in the central nervous system (CNS) These are illustrated in Figure 814 and Table 84, and are described further in 6 The ob/ob mouse develops overeating and obesity (accompanied by type 2 diabetes) due to a mutation of the ob gene that encodes leptin, the adipocyte-derived hormone that acts on the hypothalamus and other CNS regions to reduce feeding and decrease fat mass (Zhang et al, 1994) Mutations of the leptin receptor in the db/db mouse and the fa/fa Zucker rat produce a similar phenotype, because the CNS neurones that normally respond to leptin and reduce feeding are unable to recognize the hormone (Tartaglia et al, 1995) Crucial to mediating leptin s anorectic effect are neurones in the hypothalamic arcuate nucleus that express proopiomelanocortin (POMC).

These neurones release the POMC derivative, -MSH, which acts via melanocortin receptors 3 and 4 (MC4-R and MC3-R) to inhibit feeding; POMC neurones carry leptin receptors and are stimulated by leptin (see 6) Obesity in the yellow obese (Ay) mouse is due to a mutation that causes widespread overexpression of a protein termed agouti , which acts as an endogenous antagonist of -MSH at melanocortin receptors In the hypothalamus, agouti over-expression causes hyperphagia and obesity, while antagonism of -MSH in hair follicles prevents melanin formation and leaves the fur yellow..

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