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White adipocytes have evolved into the primary storage organ for surplus energy in the form of triglyceride ( 4). In so doing, they also protect other tissues from accumulating excess triglyceride. There is now much evidence that ectopic triglyceride deposition in lean tissues (skeletal and heart muscle, liver, cells and the arterial wall) can induce insulin resistance and impair other aspects of tissue function so-called lipotoxicity (Unger, 2003). The deleterious effects of ectopic triglyceride deposition are evident in human diseases and experimental animal models in which white adipose tissue is greatly reduced. In humans, the rare lipoatrophic diabetes syndrome (Seip-Berardinelli) is characterized by the

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The following is a further exploration into some of the requirements of the system. These high-level requirements must be satisfied by specific features in the PIX system.

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Motherboards and CPUs are closely linked, and this makes future upgrading of a CPU or motherboard difficult. CPUs change regularly, and every year or so new ones will replace the old and the manufacturers quickly stop making the old model, preferring to sell the newer technology. This means that as a general rule of thumb, if you try to upgrade a PC that is more than a year old, any upgrade involving the CPU or motherboard will be difficult because you will need to change both for them to be compatible (and there s a good chance that you ll need to swap out the RAM too at the same time). RAM upgrades are much easier because manufacturers continue making old types of RAM long after the technology has been superceded.

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S Matsumura, et al, Yukagaku 33, 211, 228 (1984) S Matsumura, et al, Yukagaku 34, 202, 456 (1985) S Matsumura, et al, Yukagaku 35, 167 (1985) S Matsumura, et al, Yukagaku 35, 937 (1986) S Matsumura, et al, Yukagaku 30, 31 (1980) S Matsumura, et al, Yukagaku 30, 757 (1981) T Yamamoto and K Itakura, JP Kokai 04304216 (1992) Sanyo, JP 6131498 F Kawai, JP 05237200-A, and Appl Microbiol Biotech 39(3), 382 385 (1993) Y Tani, et al, Appl Environ Microbiol 1555 1559 (1993) S Matsuo, JP Kokai, 11172039 (1999) BASF, DE 373348A, EP 289827A (1988); DE 3716543A, EP 291808A (1988); DE 3716544, EP 292766A (1988); EP 289787A (1988), EP 289788A (1988), DE 381426 (1989), US Patent 4952655 (1990), DE 4319934 (1994) NSKK, EP 529910A S Matsuo (Idemitsu), JP Kokai 2000281801 (2000) Grillo Werke, EP 289895A (1988) N Kawabata, Prog Polym Sci.

17(1), 1 (1992); Nippon Gomu Kyokaishi 66(2), 80 87 (1993) X Peng and J Shen, J Appl Polym Sci 71(12), 1953 (1999) T Yamamoto, O Kakajima, and K Katsuhiko, JP Kokai 05059130 (1993), (Mitsubishi Petro) Quantum Chemicals, US Patent, 5219930 Deutsche Golde-und Silber, US Patent 3686145 (1972); US Patent 3896086 (1975); US Patent 3923742 (1975) J Mulders and J Gilain, Water Res 11(7), 571 574 (1977) Henkel et Cie, DE2061584 (1972) Solvey et Cie, Belg Patent 786464 (1972); US Patents 4107411 (1978) and 4182806 (1980) Hoechst, A G, US Patent 3890288 (1975) Mitsubishi Petrochemicals, EP 0281139 (1988) and JP Kokai 63284296 (1989) W J Bailey, et al, Contemp Topics Polym Sci 3, 29 (1979) W J Bailey, et al, J Polym Sci, Polym Lett Edn 13, 193 (1975) W J Bailey, W J Gu, Y Lin, and Z Zheng, Makromol.

Performance degradation is such that the system or facility is unusable. Significant re-design is required. Sponsor definitely will not consider a specification change.

Chem Makromol Symp 42/43, 195 (1991) W J Bailey and B Gapud, Polym Stab Degrad 280, 423 (1985) W J Bailey and L L Zhou, Macromolecules 25(1), 3 (1992) American Cyanamid, US Patent 4923941 (1990) Toa Gosei Chemical Industry Co, JP Kokai, 2000038595 (2000) BASF, EP 4223807; US Patent 5217642; WO 9216493-A1; DE 4108626-A1 BASF, DE 4225620-A1, DE 4213282-A1 BASF, DE 4108626-A1, DE 4034334-A1 Y Abe, S Matsumura, and K Imai, Yukagaku 35(11), 937 (1986)..

Color: With Stylus selected for the Color option, the paintbrush, pencil, and airbrush lay down the foreground color at full pressure, the background color at slight pressure, and a mix of the two at medium pressure. Opacity: When you work with the pencil or the paintbrush, this option paints an opaque coat of foreground color at full pressure that dwindles to transparency at slight pressure. Similarly, varying stylus pressure adjusts the opacity of strokes that you paint with the rubber stamp, pattern stamp, eraser, history brush, and art history brush. Pressure: Here s one that I think you could probably figure out for yourself, but just in case: If you set the Pressure option to Stylus, changes in stylus pressure alter the pressure setting of the airbrush, dodge, burn, sponge, smudge, sharpen, and blur tools. Heavier stylus pressure increases the tool pressure.

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