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humidity data corroborated experimental ndings regarding the effect of the variables studied on tablet stability [180] It is known that hard gelatin capsule brittleness is a function of moisture content A study has been carried out to indicate that the brittleness of empty capsules occurred at humidities below 40% Mexitil-loaded capsules exhibited a similar pro le The SDMT model was employed to estimate the nal relative humidity for the Mexitil/gelatin capsule system and results were presented to demonstrate the general applicability of the SDMT model for predicting the incidence of brittleness problems and for the formulation to ensure the absence of brittleness [181] The sorption of two weak acids (warfarin and thiopentone) and two weak bases (chlorpromazine and diltiazem) into PVC infusion bags was described by a constant partition model.



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Consider the database design shown in Figure 20-1.

PVC water partition coef cients were obtained using three different methods: equilibrium values for sorption into PVC bags, the sorption versus pH relationship, and partition into PVC strips The data were compared with similar values derived from a liquid liquid partition system and different organic solvents (octanol, dichloromethane, carbon tetrachloride, and hexane) Octanol is the preferred solvent, and it is suggested that octanol water partition data can be used to predict sorption behavior [182] Reports have shown that changes in the hardness of tablets composed of lactose and cornstarch were due to variation of the moisture content.





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Variables are names (identifiers) that map to objects. A namespace is a dictionary of variable names (keys) and their corresponding objects (values). A Python statement can access variables in a local namespace and in the global namespace. If (heaven forfend!) a local and a global variable have the same name, the local variable shadows the global variable. Each function has its own local namespace. Class methods follow the same scoping rule as ordinary functions. Python accesses object attributes via the self argument; attributes are not brought separately into the namespace. At the module level, or in an interactive session, the local namespace is the same as the global namespace. For purposes of an eval, exec, execfile, or input statement, the local namespace is the same as the caller s.

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The two lenses could be replaced by a single lens, but two lenses serve to facilitate the elimination of aberrations produced by the lenses. The visibility is equal to 1 only if the two beams have the same irradiance; but since the two beams are differently expanded, this is possible only if the re ectance R and the transmittance F of the beam splitter satisfy the equation R F 2 f2 : f1 5:15

Neff (I0 ) N0 (I0 )

Further it was shown that the hardness of the tablets in moisture-semipermeable packages (such as strip packs and press-through packs with or without an overwrap lm) could be predicted by an iterative calculation procedure through a mathematical model based on the physicochemical properties of the tablets and the moisture permeabilities of the packaging materials [183] In another study by the same research group, moisture and temperature were used to predict the shelf-life of packaged tablets Cognizance was taken of the unctuations of temperature and relative humidity during prolonged storage A sugar-coated tablet with a core containing ascorbic acid whose color is affected by both moisture content and ambient temperature was investigated.

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Human platelet lysate can be obtained from buffy coat derived platelet rich plasma. The platelet fraction is separated from the plasma and the white and red blood cell fraction by centrifugation steps and concentrated to a density of at least 1 109 platelets/mL. Platelets can either be activated with thrombin or lysed by repeated freeze thaw cycles. Both mechanisms result in the release of growth factors and mitogens that are stored in intact platelets. Mediators released from platelets include, among others, epidermal growth factor (EGF), basic broblast growth factor (bFGF), platelet-derived growth factors (PDGFs), transforming growth factor (TGF- 1), and insulinlike growth factor (IGF) [23, 24]. Perhaps HPL may replace FBS in many

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