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Initial laboratory testing should include a complete blood count to evaluate for anemia or leukocytosis, and a urine or serum beta-human chorionic gonadotropin ( -hCG) measurement to exclude a pregnancy-related etiology. Elevated hCG can also indicate gestational trophoblastic disease or a gem cell tumor. Assessment of germ cell tumor markers, including -hCG, alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH), is indicated when imaging shows a solid or complex adnexal mass in an adolescent or young woman. In a 45-year-old patient, obtaining germ cell tumor markers would be inappropriate. If this patient has ovarian cancer, it is most likely epithelial in origin. CA-125 and CEA would be the two tumor markers that might be considered useful in the evaluation of this patient. It must always be remembered that only 80% of ovarian cancers will have an elevated CA-125 value (20% false negative), and that CA125 is only elevated in from 25% to 50% of stage I ovarian cancers. Conversely, there are a host of benign conditions that will falsely elevate CA-125 (Table 8.3). Therefore, the CA-125 value must be interpreted in the context of the patient s age, symptoms, and ultrasound characteristics of the mass. The patient s serum CA-125 is 12 U/mL (normal is 35 U/mL) and her ultrasound shows a 5-cm cystic left adnexal mass that is predominantly cystic but has a solid area without increased ow on Doppler (Fig. 8.4). Ascites is not present, and the right ovary and uterus are normal. Given these ndings, the patient would like to know the probability that she has cancer.



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Regulatory Toxicology and Pharmacology, 8, 125 159 Sunderman, FWJ (1986) Metals and lipid peroxidation Acta Pharmacology and Toxicology, 59, 248 255 Takagi, A, K Sai, T Umemura, R Hasegawa & Y Kurokawa (1990) Signi cant increase of 8hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-thylhexyl)phthalate and di(2-ethylhexyl)adipate Japanese Journal of Cancer Research, 81, 213 215 Thornally, PJ & M Vasak (1985) Possible role for metallothionein in protection against radiationinduced oxidative stress Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals Biochimica et Biophysica Acta, 827, 36 44 Troxel, CM, AP Reddy, PE O Neal, JD Hendricks & GS Bailey (1997) In vivo a atoxins B1 metabolism and hepatic DNA adductions in zebra sh (Dania rerio) Toxicology and Applied Pharmacology, 143, 213 220 Tucker, JD & Preston RJ.





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had on the Ventura house to make the down payment. Finally, he turned over the Santa Paula house to the Ventura family. What he did, in effect, was trade his real estate services for the down payment on the Ventura house. While these approaches create tax problems that you should review with your accountant, they do address your pressing need to f ind an alternative to a down payment.

(1996) Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment Mutation Research, 365, 147 159 Turelli, M (1984) Heritable genetic variation via mutation-selection balance: Lerch s zeta meets the abdominal bristle Theoretical Population Biology, 25, 138 193 Turelli, M (1986) Gaussian versus non-Guassian genetic analysis of polygenic mutation-selection balance In: (eds Karlin, S & E Nevo) Evolutionary processes and theory Academic Press, New York, pp 607 628 Varanasi, U, M Nishimoto, WL Reichert & JE Stein (1982) Metabolism and subsequent covalent binding of benzo[a]pyrene to macromolecules in gonads and liver of ripe English sole (Parophrys vetulus) Xenobiotica, 12 (7), 417 425..

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