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Every personality disorder in DSM-IV-TR is defined as a fuzzy construct. To qualify for a particular diagnosis, a person needs to exhibit m of the n defining features. If the category were precisely defined, all criteria would be individually necessary and jointly sufficient; that is, every person who qualified for membership in the category would exhibit each and every one of the n defining features. But the members of a fuzzy category are heterogeneous: Some qualify through one subset of m criteria; others through other subsets. Therefore, two members of the category typically have some but not all features in common. Why should a personality disorder require a fuzzy definition First, various strategies allow a person to satisfy an important motive. Two people with an obsessive-compulsive personality disorder may both strive to avoid criticism or attain approval, but one may do so by being neat, careful, and orderly, whereas another may do so through prodigious amounts of work. The abstract motive would be the same, but alternate strategies (goals, specific action units) exist for satisfying the higher order motive. Second, different people react differently when the motive is frustrated. Two people with a borderline personality disorder may both feel abandoned, but one may become depressed, whereas the other may become enraged. Third, different people may cope with negative affect in different ways. One may exhibit eating binges; another, a vengeful rage; and a third, suicidal gestures. Thus, the disorder is organized around the same fundamental motive, but different strategies, emotional reactions to frustration, and ways of coping with negative affect characterize people with the same organizing motive. Because of these individual differences in strategies and reactions to frustration, the diagnostic category has to be defined as a fuzzy set.



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In relation to the rst of these factors, a certain amount of forensic hydrology can reveal the extent of wetland damage due to sustained pumping of aquifers. For instance, in an area near the Anglo Scottish border that has been the locus of increasing groundwater abstraction since the 1930s, the perception of the present generation of regulatory authorities was that there were no ecological drawbacks to the sustained pumping of wells. However, using a combination of placename evidence and the collective memories of local families long resident in the area (who through their engagement in farming hold a keen appreciation of local land drainage conditions), it was demonstrated that groundwater pumping has in fact dried up former wetlands which were previously fed by natural discharge from the local aquifers (Younger 1998).





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Figure 13-7 shows the finished UserForm for this example. For best results, start with a new workbook with only one worksheet in it. Then follow these steps:

tained heat and moisture) migrate in accordance with the laws of physics The typical grid spacings (ie cell sizes) used in AOGCMs are typically squares of about 1 1 , amounting to about 250 km 250 km near the equator, with occasional ner-scale grids using cells down to 40 km 40 km While the rst few generations of General Circulation Models (GCMs) either ignored exchanges of heat and moisture with the oceans or represented them very simplistically, the present generation of AOGCMs handle these dynamics much more realistically (Allen and Ingram 2002) Because AOGCMs are being continually re ned, climate change impact studies based upon them tend to have rather short shelflives.

The regression equation is home runs = -28.1 + 154 bat ave Predictor Coef Constant -28.149 bat ave 153.55 SE Coef T P 5.083 -5.54 0.000 19.50 7.87 0.000

In the example, these CommandButtons are named CancelButton, BackButton, NextButton, and FinishButton.

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2.2. Functional Tissue Engineering In this book, we focus on functional tissue engineering, de ned as the in vitro cultivation of tissue constructs with the structural and functional properties of the tissue being replaced. As compared to the transplantation of cells alone, engineered tissue constructs have the potential advantage of immediate functionality. As compared to transplantation of native tissues, engineered tissues can alleviate donor-recipient compatibility and disease transmission (for allografts), and donor site morbidity (for autografts). Engineered tissues can also serve as physiologically relevant models for controlled studies of cells and tissues under normal and pathological conditions [Vunjak-Novakovic and Goldstein, 2005]. Ideally, a lost or damaged tissue could be replaced by an engineered graft that can reestablish appropriate structure, composition, cell signaling, and function of the native tissue. In light of this paradigm, the clinical utility of tissue engineering will likely depend on our ability to replicate the site-speci c properties of the particular tissue across different size scales. An engineered graft should provide regeneration, rather than repair, and undergo orderly remodeling in response to environmental factors in order to provide normal function in the long term (Table 6.1). 2.3. Model System Tissue engineering generally attempts to recapitulate certain aspects of the environment present during normal development in order to stimulate functional assembly of the cells into specialized tissues. This involves the presence of

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