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Ajax . I am trying to generate and download pdf file using the library ... nb = nb +1; } }); jQuery . ajax ({ type: "post", url: " Generate_PDF .php", data: ... 2 Tricyclic antidepressants and clinically similar drugs These drugs were the mainstay of drug therapy for depression for many years They have also been effective in panic disorders, pain syndromes, and anxiety states Specific ones have been effective in OCD (clomipramine), enuresis (imipramine), psychotic depression (amoxapine), and reduction of craving in cocaine withdrawal (desipramine) TCAs are characterized more by their similarities than by their differences There is a lag in clinical response for up to several weeks, largely the result of anticholinergic side effects that prevent rapid increase in dosage They tend to affect both serotonin and norepinephrine reuptake; some drugs act mainly on the former and others principally on the latter neurotransmitter system Individuals receiving the same dosages vary markedly in therapeutic drug levels achieved (elderly patients require smaller doses), and determination of plasma drug levels is helpful when clinical response has been disappointing Nortriptyline is usually effective when plasma levels are between 50 and 150 ng/mL; imipramine at plasma levels of 200 250 ng/mL; and desipramine at plasma levels of 100 250 ng/mL High blood levels are not more effective than moderate levels and may be counterproductive (eg, delirium, seizures) Patients with gastrointestinal side effects benefit from plasma level monitoring to assess absorption of the drug Most TCAs can be given in a single dose at bedtime, starting at fairly low doses (eg, nortriptyline 25 mg orally) and increasing by 25 mg every several days as tolerated until the therapeutic response is achieved (eg, nortriptyline, 100 150 mg) or to maximum dose if necessary (eg, nortriptyline, 150 mg) The most common cause of treatment failure is an inadequate trial A full trial consists of giving maximum daily dosage for at least 6 weeks Because of marked anticholinergic and sedating side effects, clomipramine is started at a low dose (25 mg/d orally) and increased slowly in divided doses up to 100 mg/d, held at that level for several days, and then gradually increased as necessary up to 250 mg/d Any of the TCAlike drugs should be started at very low doses (eg, 10 25 mg/ d) and increased slowly in the treatment of panic disorder The TCAs have anticholinergic side effects to varying degrees (amitriptyline 100 mg is equivalent to atropine 5 mg) One must be particularly wary of the effect in elderly men with prostatic hyperplasia The anticholinergic effects also predispose to other medical problems such as heat stroke or dental problems from xerostomia Orthostatic hypotension is fairly common, is not dose-dependent and may not remit with time; this may predispose to falls and hip fractures in the elderly Cardiac effects of the TCAs are functions of the anticholinergic effect, direct myocardial depression (quinidine-like effect), and interference with adrenergic neurons These factors may produce altered rate, rhythm, and contractility, particularly in patients with preexisting cardiac disease, such as bundlebranch or bifascicular block Electrocardiographic changes range from benign ST segment and T wave changes and sinus tachycardia to a variety of complex and serious arrhythmias, the latter requiring a change in medication Because TCAs have class I antiarrhythmic effects, they should be used with caution in patients with ischemic heart disease, arrhythmias, or conduction disturbances SSRIs or the atypical antidepressants are better initial choices for this population TCAs lower the seizure threshold so this is of particular concern in patients. jquery pdf thumbnail generator: PDFKit create pdf javascript library PDFKit
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Saving web page content is a useful function to be able to integrate to your site and a very common requirement in web development. PDF documents are the ... with a propensity for seizures (eg, previous head injury, alcohol withdrawal) Loss of libido and erectile, ejaculatory, and orgasmic dysfunction are fairly common and can compromise compliance Trazodone rarely causes priapism, which requires treatment within 12 hours (epinephrine 1:1000 injected into the corpus cavernosum) Delirium, agitation, and mania are infrequent complications Sudden discontinuation of some of these drugs can produce cholinergic rebound, manifested by headaches and nausea with abdominal cramps Overdoses of TCAs are often serious because of the narrow therapeutic index and quinidine-like effects (see 38) 3 Monoamine oxidase inhibitors The MAO inhibitors are generally used as third-line drugs for depression (after a failure of SSRIs, TCAs, or the atypical antidepressants) because of the dietary and other restrictions required (see below and Table 25 7) They should be considered third-line drugs for refractory panic disorder and depression; however, this has changed since MAO inhibitor skin patches (selegilene) have become available They deliver the MAO inhibitor to the bloodstream bypassing the gastrointestinal tract so that dietary restrictions are not necessary in the lowest dosage strength (6 mg/24h) Oral MAO inhibitors are administered in gradual stepwise dosage and may be given in the morning or evening, depending upon their effect on sleep They tend to take effect in a fairly low dosage range (Table 25 8) Blood levels are not congruent with therapeutic response The MAO inhibitors commonly cause symptoms of orthostatic hypotension (which may persist) and sympathomimetic effects of tachycardia, sweating, and tremor Nausea, insomnia (often associated with intense afternoon drowsiness), and sexual dysfunction are common Trazodone, 25 75 mg orally at bedtime, may ameliorate the MAO-induced insomnia Central nervous system effects include agitation and toxic psychoses Dietary limitations (Table 25 7) and abstinence from drug products containing phenylpropanolamine, phenylephrine, meperidine, dextromethorphan, and pseudoephedrine are mandatory for MAO-A type inhibitors (those marketed for treatment of depression), since the reduction of available MAO leaves the patient vulnerable to exogenous amines (eg, tyramine in foodstuffs) Treatment for a resultant hypertensive crisis has been the same as for pheochromocytoma (see 26), but there have been reports of success with nifedipine, 10 mg chewed and placed under the tongue, normalizing blood pressure in 1 5 minutes The restrictions on the proscribed foodstuffs and sympathomimetic drugs are in effect during treatment and for. javascript create pdf library folioGallery is a Free PHP, jQuery , Ajax Photo Gallery, No Database ...
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