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needs to forward a packet may choose to use such a tunnel instead of forwarding the packet to the next router Of course such a choice exists only if a tunnel to the particular destination is available, and if the packet is in the traf c aggregate for which the network uses this special service Of course, it may not be possible to construct such sink trees for every possible destination in the Internet (although it may be possible in private IP networks) MPLS is mainly used in the core of the Internet where each router i at the periphery of the core is responsible for handling the traf c to and from a speci c set of networks Ni .



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The year 2003 marks the ftieth anniversary of the discovery of the double helix structure of DNA by Crick and Watson. It also marks the completion date for the sequencing phase of the Human Genome Project (HGP), of cially begun in 1990. In a mere thirteen years the public consortium of researchers has mapped and sequenced the entire human genome of over three billion base pairs (International Human Genome Sequencing Consortium, 2001). A private company, Celera Genomics, sequenced substantially all of the human genome in an even shorter period of time (Venter et al., 2001). In the postgenome stage of research, scientists are constructing haplotype maps, sequencing the genomes of other model organisms, and applying genome-wide research techniques to the study of proteins and the development of pharmaceutical products (see chapter by Mohrenweiser, this volume). The principal reason for publicly funding genome research is the prospect of preventing, diagnosing, and treating diseases. Because of the speed at which various diseases have been linked with genetic loci and the publicity surrounding each new discovery, it is understandable that the public would believe that treatments and cures for dreaded diseases would begin owing shortly after each new gene discovery. Unfortunately, although genomic knowledge has been increasing exponentially, clinical





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Of course, your technology leaders will need to stay abreast of changes in technology, so an ongoing program should be developed to meet their needs. Are there conferences they should attend Should the organization purchase a small collection of books, manuals, and magazines devoted to technology All of these components should be melded together into a brief list of leadership objectives, including a timeline for achieving goals, and a budget to cover essential expenses. For a technology program to be successful, nonprofit decision makers must actively support technology. This means that board members cannot be computerphobes who regard technology as none of their concern. Leadership in any nonprofit comes from its board, so board members must be the first to receive support. Although they need not be highly sophisticated computer users, board members must fully understand what technology can and cannot do for their organization.This may mean working with a consultant or conducting special training sessions for board members. Exhibit 1.4 summarizes the elements that together make an effective technology plan.

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a Fund Number 0.1 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.5 1 1 1 1 1 734 735 547 1046 1268 722 931 161 1241 929 931 161 722 929 439

Each such edge router i has an established label-switched path from each other edge router, and is also the sink of a tree of paths which connect all members of N j to it When an edge router i detects the start of a ow of packets which require a speci c quality of transport with a destination of a network in the responsibility of router i, it forwards the packets through the corresponding prede ned label switched path (of which there may be more than one for the same destination, with different quality of service parameters) Otherwise, the ow is treated as ordinary IP ow and packets are forwarded to the next IP router inside the core.

Reproduced with permission from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Copyright 1994 American Psychiatric Association.

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In general, these ideas can be used for traf c aggregates of arbitrary de nitions (not only those based on the packet s IP destination address), such as video traf c, or other traf c that is considered of higher priority The network manager must rst design these high-quality MPLS tunnels, program them into the network infrastructure, and then specify the traf c aggregate that should use the MPLS service Hence, at each entry node one must rst associate each traf c aggregates with a corresponding label switched path originating at that node.

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