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best of our knowledge, there is no report in the literature on chemically-induced aneuploidy in sh Chromosomal damage can also arise by the misrepair or misreplication of damaged DNA This constitutes a structural chromosome aberration which is the primary target for the induction of chromosomal damage All types of damage in chromosome structure such as asymmetrical exchanges (dicentrics and rings) and deletions (terminal and interstitial) lead to the loss of chromosomal material at mitosis, or the inhibition of accurate chromosome segregation at anaphase, which can result nally in cell death (Tucker & Preston, 1996) Some of these events such as deletions and ring and dicentric chromosomes may yield chromatin pieces, also called acentric fragments that lack a centromere and are incorporated into micronuclei (section 2333) Jha et al.





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Ural II had 4 K of memory, a miniscule amount by today s standards, about as much as one of the rst personal computers of the 1970s Following his experience with the Ural II, Simonyi decided to pursue his interest in computer programming His rst programming effort was to write a compiler program for the government Subsequently, at a trade fair in Budapest, Simonyi had the opportunity to interact with foreigners from Denmark He presented a demonstration of his compiler to the members of a Danish computer trade delegation He was soon contacted about a job At the age of 16, he left his family and moved to the West Simonyi spent the next year writing software in Denmark while saving his money so that he could pursue an advanced education He then enrolled as a student at the University of California at Berkeley and graduated in 1972.

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(1996) observed that exposure of embryo-larval polychaetes to mitomycin C, methanesulphonate, cyclophosphamide and benzo[a]pyrene leads to a dose-related induction of chromosomal aberrations Al-Sabti and Kurelec (1985) detected chromosomal aberrations in gill cells from mussels that were transferred from a clean site to a site polluted with untreated domestic and harbour wastes In the same study they observed a dose-response of chromosome aberrations induction in mussels exposed to benzo[a]pyrene in the laboratory Different chromosomal aberrations, such as breaks, ring chromosomes and dicentric chromosomes, have been detected in kidney cells after the injection of three sh species (common carp, Cyprinus carpio; tench, Tinca tinca; grass carp, Ctenopharyngodon idella) with a atoxin B1, aroclor 1254, benzidine, benzo[a]pyrene and 20-methylcholanthrene Besides, these chromosomal aberrations are induced in a dose-dependent manner in the three sh species tested, although the level of chromosomal aberrations induced by each chemical differed in each sh species (Al-Sabti, 1985) 2.

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At this time, he was recruited to work at Xerox PARC He continued his education by registering in a doctoral program at nearby Stanford University His doctoral thesis was on the methods he had developed to write software Charles Simonyi was an extremely talented programmer a software artist For an artist to create a painting masterpiece, an artist must have superb imagination To create a software masterpiece, a software artist must have superb memory Different people have different abilities when it comes to memory, but only a select few have unusual abilities to remember things For example, it is unusual to nd a person who can remember more than nine randomly selected numbers at a time Nevertheless, it is said that it takes a person with such ability to be able to write really good computer programs.

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