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Management of CIN is decided based on the natural history of the disease. In this clinical scenario, the patient is a young woman with a CIN 1 lesion. The chance for regression is upwards of 90%, so she may be followed with observation by repeat cytology. If she undergoes two serial Pap smears 6 months apart that are both normal, she may return to annual screening. If an abnormal Pap returns, a repeat coloposcopy is necessary. Persistent CIN1 is less likely to resolve, thus treatment might be considered in certain patients. However, there is no harm in following the patient clinically because the risk for disease progression in the face of persistent CIN 1 is very low. Bansal and associates reported a risk for progression to HGSIL after 6 months of persistent disease to be only 4%.16 We recommend that, especially in young nulliparous patients, persistent CIN 1 should be managed with observation rather than ablative or excisional therapies that might compromise fertility and obstetrical outcomes. As there is less chance for regression and a higher risk for disease progression, CIN 2 and CIN 3 lesions are typically managed with either an ablative or excisional procedure. It is estimated that almost half of CIN 2 lesions will regress, but since the majority will either persist or progress, treatment is indicated in most scenarios. If a patient is compliant and prefers to be followed, she should undergo cytology and colposcopy at 6-month intervals. This should be undertaken only if the



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Commonwealth of Pennsylvania (1971, 1972) and Mills v Board of Education (1972), the courts ruled that exclusion of children with handicaps from public school education is a denial of equal protection In the years since Brown, the courts have sent an unwavering message to the states that they have a duty to provide equal educational opportunities to all children regardless of race, color, national origin, native language, sex, and disability under the 14th Amendment (see 6) The 14th Amendment equal protection clause also has protected school access rights of pregnant and married students Due Process The 14th Amendment also provides that no state shall deprive any person of life, liberty, or property, without due process of law Courts have identified two aspects of due process: substantive and procedural Substantive due process applies to the content of a law.

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10. All references to Hollinger-Clark are found in Wells, 25 26. See also note 9. 11. White Collar Crime Study, FBI National Press Office (March 6, 2002). 12. See note 1, 29 30. 13. Id., 31 32. 14. Id., 32. See also note 9. 15. James S. Bowman, Ethics in Government: A National Survey of Public Administrators,

ef ciency of analysis and improved speci city and sensitivity for detecting both subtle and complicated alterations, particularly reciprocal translocations (MacGregor et al, 1995) Probes for different chromosomes can be labelled in different colours and can be combined to analyse cells for alterations in chromosome structure and number One de ciency of chromosome painting is that the method only detects exchanges that occur between chromosomes painted with different colours or between chromosomes painted in the same colour but with suf ciently different staining intensity (Preston, 1996) Another limitation of FISH is that multiple copies of a target sequence are needed for detection The use of the in situ polymerase chain reaction that yields to the multiplication of target DNA sequences in combination with FISH (ISPCR) has enabled the detection of single copies of DNA (Zhang et al, 1997; Engelen et al, 1998).

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CRIME PREVENTION Table 2.6.1 Summary of action system modes of functioning Source of action External External Internal Internal Locus of effect External Internal External Internal Mode Adaptive Conservative Expressive Integrative

These procedures, although well developed for mammals, are not widely applied in sh Zhang et al (1999) developed an ISPCR technique able to detect a single-locus gene on cat sh chromosomes Painting probes for human chromosomes have been widely used and are available from several commercial sources Many approaches have been developed for testing aneuploidy in human sperm using DNA probes (for chromosome-speci c repetitive sequences or high complexity probes) repetitive, multiple dyes and FISH (MacGregor et al, 1995) However, development of painting probes for chromosomes of other species is more recent, because of the greater dif culty in obtaining pure individual chromosomes as a source for probe development No information is available about painting probes for sh chromosomes Chromosome painting can be incorporated into existing toxicology studies without altering the exposure protocols normally employed and can provide important information about tissue-speci c genotoxic effects (MacGregor et al.

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