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The rise of biotechnology rms, often with academic researchers as holders of stock or stock options, has added new commercial interest to genomic research So have universities, hungry for the royalty payments encouraged by the Bayh Dole Act of 1980 and demonstrated by the Cohen Boyer patent on recombinant DNA, which, during its 17-year life, earned Stanford and the University of California about $200 million Outside of governments, human genomic research is now largely done by corporations, by academic scientists working with corporations, or by academic scientists whose universities are eager to nd commercial opportunities in faculty research Exceptions continue to exist, particularly in areas of human genetics not focused on disease, but they are not the rule At the same time, at least some of the research has moved away from a focus on family diseases.



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The voltage attenuation, A, of the attenuator is given by A= R + R0 R1 R0 R + R0 R + R0 + R1 R0 (13.55)





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So-called associative research looks broadly for correlations between genomic data and medical information; pharmacogenomic research tries to nd links between genetic variations and responsiveness to drugs In both cases, the health of the research subject and his or her family is much less directly implicated Under these circumstances, it may be unrealistic to expect research subjects to give scientists their DNA, family histories, and medical records for free If the scientists are looking for millions, prospective research subjects may well wonder why their contribution should be uncompensated On the other hand, it is extremely rare that any one individual research subject leads to a genetic breakthrough Locating and cloning disease genes usually requires contributions of medical histories and DNA from thousands of subjects Any one subject who held out for payment could be bypassed Group research, on the other hand, may provide a group with realistic bargaining power.

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A particular algorithm may have been chosen for asymptotic performance that is irrelevant to the current data analysis, may not lend itself easily to accurate implementation, or may elide crucial details regarding the handling of numerical errors or boundary details Both algorithm and implementation must be considered when evaluating accuracy To summarize, an algorithm is a procedure for solving a well-de ned problem An algorithm is correct when given an instance of a problem, it can be proved to produce an output with well-de ned characteristics An algorithm may be correct but still lead to inaccurate implementations Furthermore, in choosing and implementing algorithms to solve a particular problem, there are often tradeoffs between accuracy and ef ciency In the next section we discuss the role of algorithms and implementations in inference..

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The results of studies examining the visual-spatial domain in children with sickle cell are equivocal. One study examined visual-spatial de cits in children with stroke (n 33) and children without stroke (n 43) (Schatz, Craft, Koby, & DeBaun, 2004). Children with unilateral left (n 14) or right (n 7) injury showed less ef cient visual search

it to the regulator. It turns out that information asymmetry is always to the advantage of the rm, who can use it to extract a more favourable contract from the regulator. By trying to squeeze more of the pro ts of the rm from the contract, the regulator can only have negative effects on social ef ciency. Let us investigate the problems that the regulator must solve in each case. In the case of hidden action asymmetry the principal knows the cost function c.a/ (where for simplicity we suppose this cost depends only upon the action taken), but he cannot directly observe a. The principal s problem is to design a payment scheme w.x/ that induces the socially best action from the agent. Let u.x/ be the utility to the society of a production level x. The problem can be solved in two steps. First, compute the socially optimal action by nding the value of a that solves the problem # " n X a pi u.xi / c.a/ maximize

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