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Suppose planners allow any arriving train to be divided in at most nmax subtrains In case no solution exists in which none of the arriving trains is divided, nmax should be set greater than 1 to prevent the algorithm getting stuck To facilitate a smooth departure, planners might be forced to accept the division of some arriving trains The algorithm Matching evaluates Cmatch for all possible combinations of divisions (a1, a2, , an) and positions (p1, p2, , pn), where n ranges from 1 to nmax During this process the best possibility is stored in (a1, a2, , an; p1, 4 p2, , pn) According to the nal best solution the algorithm Matching positions the material of train a onto the blueprint Thus, the algorithm matches the arriving train units and the departing train units at their corresponding positions This process is repeated for all trains a [ A.



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2, 1961] [17], and the requirements for manufacturing and quality controls in MHLW Ministerial Ordinance No 95, 2003 Regulations for Manufacturing Control and Quality Control of Drugs (originally MHW Ministerial Ordinance No 3, 1994) As a member of the ICH Japan has adopted the ICH guidance document Q7, Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, and published it as Pharmaceutical and Food Safety Bureau (PFSB) Director-General Noti cation No 1200, 2001 Guidelines on GMP for Drug Substances, which states the requirements for the manufacture of APIs The requirements concerning imported drug products are given in MHLW Ministerial Ordinance No 97, 2003 Regulations for Importing/Retail Management and Quality Control of Drugs and Quasi-Drugs (originally MHW Ministerial Ordinance No 62, 1999) The requirements specifying manufacture of investigational products are given in PAB Noti cation No.





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480, 1997 Products and Standards for the Buildings and Facilities of Manufacturing Plants for Investigational Products (Investigational Product GMP) [2] South Korea The production of drug products (drugs) in South Korea is regulated under the Pharmaceutical Affairs Law, which was rst enacted in 1953 and has since been revised several times [18] New drug approval and related activities are regulated in much the same way as in the United States and Japan Korean GMP, which is often called KGMP, was initiated in 1984 and became mandatory in 1995 [19] A drug manufacturer who intends to manufacture a drug product for sale in Korea must have approval from the Commissioner of the Korea Food and Drug Administration (KFDA) In order to require the license for manufacturing business the manufacturer has to prove the compliance of facility standards with KGMP [20].

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China China regulates the production of drug products (drugs) under the Drug Administration Law of the People s Republic of China, which states that a drug manufacturer has to conduct drug manufacture according to the GMP for pharmaceutical products formulated by the Drug Regulatory Department under the State Council on the basis of the Drug Administration Law [21] In June 2004 GMP became mandatory in China and the State Drug Administration announced that local drug manufacturing establishments lacking approved GMP certi cation would not be allowed to continue the production of pharmaceuticals [22]..

Figure 168 summarizes the process by showing the algorithm Matching in pseudo code Before we explain how the one-period heuristic is used in the multiple-period heuristic, let us summarize the heuristic so far After the phase of making a blueprint of the departing trains D, the heuristic matches the material of the arriving trains A onto the blueprint Since we have assumed to this point that the number of departing train units equals the number of arriving train units, all train units are matched and positioned 1622 The Multiple-Period Heuristic This section presents the heuristic that solves real shunting problems by using the one-period heuristic as a building block We call the heuristic the multiple-period heuristic In principal the one-period heuristic assumes that no train leaves the marshaling yard before the last train arrives at the marshaling yard.

dissipation rate, respectively. According to (23), the reconstructed variables (denoted below by tilde), for a two-dimensional Cartesian co-ordinate system1 by

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