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women and minorities in clinical research. The government would be funding a study that only African Americans could enter, so a racial classi cation is involved. In this case whites are excluded because there is evidence that the drug will not work for them but may for African Americans. Because most studies for heart disease have included white patients, indeed, have disproportionately bene ted them in the past, whites are not being disadvantaged by this instance of government funding of a study that focuses exclusively on a drug that might work in African American heart patients. Without the study, many African Americans may be left with few effective treatments for heart disease, when most whites can be treated with beta-blockers and ACE inhibitors. Nor are whites denied research funding, for there has been ample study of therapies that bene t whites disproportionately, if not exclusively. Whether there will be suf cient funding for such studies depends on the NIH s and the public s commitment to improving the health care of minority populations, for example, its willingness to ask for and get budgetary support, and then awarding grants to researchers studying these questions. After a long disregard of the health needs of African Americans, there is now a willingness to fund more race-related research. With the large budget increases given to the NIH in recent years and the past neglect of minority health, even larger increases for minority health care should be acceptable. With wide discretion to spend resources to improve the general welfare, Congress and federal agencies may use race and ethnicity in research and treatment funding decisions when medical evidence shows that racial and ethnic differences affect health care.



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Of course, we can t know for certain if caves were chosen to protect the paintings from the weather or to demonstrate the bravery of the warriors who had to enter the lair of the ferocious cave bear to paint and see them Maybe the difficult entry and the inhospitably dark environment lent enough danger and mystery to the location to enhance its ritualistic purpose Whatever the reason, knowledge was recorded, stored, and passed along in a dedicated space, another key element of good knowledge networking The cave itself lent special importance to what the community learned from its contents Surely these paintings were created and preserved for some purpose beyond the quality of their art Though we can recognize most of the animal forms, we can t understand the context of their creation.

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mentioned in the PRAM Guide, because it was not fully developed at the time chap 3 of the PRAM Guide was developed An operational de ne phase that is holistic and integrated requires a six W s structure equivalent In addition, Ward s development of the PLC structure (Ward and Chapman, 1995b), as outlined in 2, is central to our thinking, but its use in the PRAM Guide is limited to describing risk management in the plan stage of the PLC The role of the PLC as a driver of the focus phase was clear at the time chap 3 of the PRAM Guide was developed, but its use as a basis for the de ne phase was not developed at that time Like the six W s, it is crucial to a holistic and integrated de ne phase.

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A holistic de ne phase needs to consider the cash ow and associated multiple criteria models that integrate the six W s and the PLC This issue was not addressed by the PRAM working party A third difference relates to the harness phase As described in this book, the harness phase is broadly equivalent to the planning phase of the PRAM framework However, the PRAM Guide s section 26 description of the planning phase embraces aspects of risk response development (seeking risk ef ciency in our terms) that we associate with the shape phases, and it omits the initiation of detailed planning for implementation within an action horizon determined by lead times that we believe should be deferred until looping back to earlier phases is largely over Figure 41 shows two important loops back from the evaluate phase, but no loops back from the harness phase.

High: Must be implemented in the current iteration Moderate: Candidate for implementation in the next iteration (could be implemented in this iteration if all high-priority requirements have been completely implemented) Low: Candidate for implementation after two or more iterations (could be implemented in this iteration if all high- and moderate-priority requirements have been completely implemented)

We may be the distant descendants of the cave painters, but the best we can do is guess that these paintings had meaning and solved problems for the clan They could have created them to keep clan members safe, to keep them fed, or simply to allay their fears In the lingo of modern knowledge management, the art in Chauvet Cave would be described as.

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