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Pathways to Symptom Expression As always, it is important to remember that there is a logic that connects the personality pattern with its associated Axis I syndromes. Because ambivalence is felt subjectively as anxiety, moodiness, and discontent, negativists are likely to experience anxiety disorders, often tinged with depressive complaints. Such feelings crystallize and vent their tensions and provide a subtle means of expressing anger and resentment. To an extent, anxiety is instrumental. Usually, tension is discharged in brief episodes of passiveaggressive behavior or through verbal channels. When this is not possible, however, panic attacks or generalized anxiety can develop. Phobic symptoms may be used for secondary gain by giving negativists a reason not to meet the expectations of others or to excuse themselves from task demands. Other disorders can also occur. Depressive episodes are common, ranging from occasional severe depressive episodes to a more subtle but pervasive dysthymia. Negativistic personalities most frequently display an agitated dysphoria, vacillating between anxious futility, despair, and self-deprecation on the one hand and a bitter discontent and demanding irritability on the other. Such sour moods and complaints also ruin things for others and give the negativist compensatory feelings of retribution. Somatoform disorders are not unusual in situations of unresolvable conflict, but they usually have an added, passive-aggressive benefit that makes them especially burdensome to others. Finally, negativists share with the paranoid a deep concern about autonomy and external control, suggesting that paranoid decompensation could occur in some cases.

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dimensions. Step 3 considers associated responses. Step 4 considers associated secondary sources and responses. Step 5 elaborates on the very basic search process used to kick off the rst ve steps. A speci c assess task then initiates loops back to earlier steps if necessary. As with Figures 5.1 and 6.1, the Figure 7.1 portrayal of the identify phase is deliberately simpli ed to illustrate the spirit of what is involved. In practice, things may not happen according to this model, but the model is a useful target that can help to maintain focus and order. The identify phase involves the identi cation of at least one assumed response for each identi ed source. A generic do nothing response is one option, but this will not be appropriate in some cases. A preliminary list of obvious response options indicating preferences associated with all sources is a recommended output on a rst pass. Detailed lists of response options may be deferred until later passes for those sources that prove signi cant, but early identi cation of response options can form the basis of a concerted opportunity identi cation process that goes beyond simple threat management. Risk ef ciency is about generating options that may lead to better plans, responses to sources providing the starting point from an RMP perspective.

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Aldridge, S., Customizing Drugs to Individual Genetic Pro les, Genet. Eng. News, 21 (14), 29, 67 (2001). AMCP Format for Formulary Submissions. www.amcp.org/publications Bioworld. The BioWorld Biotechnology State of the Industry Report, 1998 2001 (2001). www.bioworld.com/bw/public.htm path=resources/ann/index.html Bootman, J.L., et al., Principles of Pharmacoeconomics, Cincinnati, OH: Harvey Whitney Books Company, p. 35 (1991). Cutler, D.M. and M. McClellan, Is technology change in medicine worth it Hlth. Affairs, 20 (5), 11 29 (2001). Danzon, P. and A. Towse, The Genomic Revolution: Is The Real Risk UnderInvestment Rather Than Bankrupt Health Care Systems J. Hlth. Serv. Res. Policy, 5 (4), 253 255 (2000). Department of Health and Human Services, National Institutes of Health. Diseasespeci c Estimates of Direct and Indirect Costs of Illness and NIH Support. (2000). www1.od.nih.gov/osp/ospp/ecostudies/COIreportweb.htm DiMasi, J., Risks, Regulations, and Rewards in New Drug Development in the United States, Regul. Toxicol. Pharmacol. 19, 228 235 (1994). DiMasi, J., et al., Cost of Innovation in the Pharmaceutical Industry, J. Hlth. Econ., 10, 107 142 (1991). Drews, J., Drug Discovery: A Historical Perspective, Science, 287, 1960 1964 (2000). Drummond, M.F., et al., Methods for the Economic Evaluation of Health Care Programs, Oxford: Oxford University Press, pp. 6 17 (1997). Eisenberg, J.M., Clinical Economics: A Guide to the Economic Analysis of Clinical Practices, JAMA, 262, 2879 2886 (1989). Emilien, G., et al., Impact of Genomics on Drug Discovery and Clinical Medicine, Q. J. Med., 93, 391 423 (2000). Ernst, F.R. and A.J. Grizzle, Drug-Related Morbidity and Mortality: Updating the Cost-of-Illness Model, J. Am. Pharmaceut. Assn., 41 (2), 192 199 (2001).

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4, Synchronization Patterns, describes four patterns that alleviate the problems described above to simplify serialization and locking in concurrent systems. These patterns are Scoped Locking (325), Strategized Locking (333), Thread-Safe Interface (345), and Double-Checked Locking Optimization (353).

B.2 NO MISSION DATA Regardless of whether the MPL entry, descent, and landing (EDL) phases were in fact successful, there remains one direct outcome: desired scienti c data regarding water or ice on Mars will very likely never be obtained from the MPL mission. That outcome is simply because no signal was received after MPL s initial descent. What happened What might have prevented it Could software development process automation have prevented this mission failure (See Figure B.2.) While identi cation of a single root cause potentially enables speci c process improvements to address the issue, there can be cases of multiple or inde nite causes. Some defects representing candidate causes may be found during the course of an investigation. The question of whether a product has a defect may still be addressed, regardless of whether a cause of a speci c incident is fully understood.

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