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Malignant melanoma is the leading cause of death due to skin disease There were 55,000 cases of melanoma in the United States in 2004, with 7900 deaths One in four cases of melanoma occur before the age of 40 Overall survival for melanomas in whites has risen from 60% in 1960 1963 to more than 85% currently, primarily due to earlier detection of lesions Tumor thickness is the single most important prognostic factor Ten-year survival rates related to thickness in millimeters are as follows: < 1 mm, 95%; 1 2 mm, 80%; 2 4 mm, 55%; and > 4 mm, 30% With lymph node involvement, the 5-year survival rate is 30%; with distant metastases, it is less than 10% More accurate prognoses can be made on the basis of site, histologic features, and gender of the patient

Clinical practice guidelines exist for the evaluation and treatment of patients with benign prostatic hyperplasia (Figure 23 2) Following evaluation as outlined above, patients should be offered various forms of therapy for benign prostatic hyperplasia Patients are advised to consult with their primary care physicians and make an educated decision on the basis of the relative efficacy and side effects of the treatment options (Table 23 5) Patients with mild symptoms (AUA scores 0 7) should be managed by watchful waiting only Absolute surgical indications are refractory urinary retention (failing at least one attempt at catheter removal), large bladder diverticula, or any of the following sequelae of benign prostatic hyperplasia: recurrent urinary tract infection, recurrent gross hematuria, bladder stones, or renal insufficiency

Example A-51. The solution to Exercise 17-2

TUIP 78 83% 73% 22 333% 02 15% 01 11% 13 27% 39 245% 6 55% 7 21 1 3

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Open Surgery 94 998% 79% 7 427% 1 46% 03 07% 06 141% 47 392% 36 95% 21 28 5 10

TURP 75 96% 85% 52 307% 05 33% 07 14% 07 101% 33 348% 25 99% 7 21 3 5

Watchful Waiting 31 55% Unknown 1 5% 08% 2% 0 3% 0 1 0

// the delegate public delegate void TimesUpEventHandler ( object countDownClock, CountDownClockEventArgs alarmInformation ); // an instance of the delegate public event TimesUpEventHandler TimeExpired;

Blockers 59 86% 51% 29 433% 08% 2% 0 3% 4 11% 35 0

Finasteride2 54 78% 31% 136 88% 08% 2% 0 25 53% 0 15 0

Degree of symptom improvement (% reduction in symptom score) Morbidity and complications1 Death within 30 90 days1 Total incontinence

Solution to Exercise 17-3. Rewrite the observer class in Exercise 17-2 to use an anonymous method. You may have noticed that the event handler method in Exercises 17-1 and 17-2 is pretty simple; all it does is output the message to the console. This is a perfect candidate for an anonymous method. To make the method anonymous, you need to delete the code that instantiates the handler, and instead move the call to Console. WriteLine to the line that registers the handler. The only changes here are to the observer class, so that s all that Example A-52 shows.

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Need for operative treatment for surgical complications1 Impotence1 Retrograde ejaculation Loss of work in days Hospital stay in days

90% confidence interval Most of the data reviewed for finasteride are derived from three trials that have required an enlarged prostate for entry The chance of improvement in men with symptoms yet minimally enlarged prostates may be much less, as noted from the VA Cooperative Trial TUIP, transurethral incision of the prostate; TURP, transurethral resection of the prostate

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