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Insulin is the last therapeutic resort for type 2 diabetic patients who fail to respond to lifestyle improvement and oral agents It can always lower blood glucose if enough is given; very large dosages ( 150 units per day) may be required in morbidly obese and very insulin-resistant patients, and many obese subjects need dosages exceeding 1 U/kg/day to achieve acceptable glycaemic control Hypoglycaemia and increased adiposity are the main problems in using insulin to treat obese type 2 diabetic patients Hypoglycaemia is particularly troublesome with intensive regimens (especially multiple daily injections), with high dosages, and when insulin is combined with sulphonylureas Weight gain is typically 4 5 kg This is attributed mainly to the anabolic and lipogenic effects of insulin (see 4), and initially to decreasing losses of glucose in the urine, which can amount to several hundred kcal per day in poorly controlled subjects.



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Hypoglycaemia also induces intense hunger, and food intake can increase signi cantly in patients with frequent episodes The operations and their outcomes are described in 18 Various procedures can achieve substantial weight loss (up to 80% of excess weight), notably the biliopancreatic diversion (BPD), Roux-en-Y gastric bypass (RYGBP) and gastric banding Blood glucose levels fall dramatically, and normoglycaemia can be restored in up to 80% of cases with IGT or even established type 2 diabetes treated with BPD or RYGBP (Buchwald et al, 2004) (Figure 198) Patients with long-standing diabetes and those taking high insulin dosages are less likely to respond Some patients eventually regain some weight after the post-operative fall (see 18), and glucose intolerance and ultimately overt diabetes may return Successful bariatric surgery also improves hypertension, dyslipidaemia and sleep apnoea (Maggard et al, 2005) (Figure 198).

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General indications for bariatric surgery are discussed in 18 Obese subjects with type 2 diabetes could be considered if their BMI exceeds 35 kg/m2; if their obesity is likely to be the main impediment to achieving good glycaemic control and has resisted other measures; or if other serious obesity related co-morbidities are present..

s 7 through 9 discuss recording considerations and the actual recording of your podcast. I outline the postproduction process for creating a stellar audio recording using equipment that you own. s 10 through 12 discuss hosting solutions and what to watch out for, including the realities of distributing audio and my secret hosting solutions. I cover publishing your podcast on the Internet and how to implement RSS feeds with or without a weblog. s 13 through 14 cover the actual publishing and promotion of your podcast and how to integrate a marketing and promotion strategy to include advertising. Finally, in 15, I discuss the road ahead. How will podcasting affect traditional radio and what will the impact of commercialization be

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Removing a PEAR package is just as easy as installing. Simply run the package manager with the uninstall command, followed by the name of the package to uninstall:

Considerable investigations in the literature have gone into the design of the prototype filters { H ( z ) ,R ( z ) } , consequently into the design of analysis and synthesis filter banks, and in order to reduce the distortion and delay between the input and output nodes (such as the design of perfect reconstruction filter banks). Such studies are well-documented in textbooks on multi-rate discrete-time signal processing (see, e.g., Vaidyanathan (1993)). When the subband signals are modified (due to overlaps in their spectra), cross-filters may be needed in order to reduce signal distortion (see, e.g., Gilloire and Vetterli (1992)).

Let us apply what we have just learned to write the equations forth e network in Fig. 3.7 by inspec tion. Then given the fo llowing parameters, we will delennine the node voltages using MATLAB: R, = R, = 2 kn, R, = R, = 4 kn, R, = I kn, iA = 4 mA , and i ll = 2 rnA.

There is potentially a wide variety of nonlinear physical mechanisms that can be used for optical phase conjugation of coherent laser beams. The generation of a phase conjugate wavefront arises from the third-order material nonlinearity; moreover, analogy with holography introduced above affords the opportunity of using materials allowing the recording of phase or amplitude dynamic volume of the holograms. Therefore, the mechanisms presented hereafter have been the subject of extensive research activities during the last two decades both on the basic material properties and in depth analysis of interactions between beams that interfere in the volume of the nonlinear media. 1.3.1 Optical Kerr effects

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The Facet effect creates a painterly effect by grouping similarly colored pixels together within a clip.

Figure 21-12: Dragging a picture track into place in the Tracks List. The dark line shows you where it is due to land.

Risk watch list (List of major risks identified for risk treatment)

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