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Life satisfaction seems to have a curvilinear relationship with age among young adults: Those in late adolescence and in their late twenties seem to have lower life satisfaction, particularly if they are not working (Putzke, Richards, & Dowler, 2000a) Stressful life events may have different effects on persons with SCI as a function of their age, which in turn may re ect different developmental tasks across the lifespan (Frank, Elliott, Buckelew, & Haut, 1988) Surveys indicate that younger persons with SCI are more interested in topics that concern sexuality, fertility, family planning, muscle function test, and nerve conductance, and are less interested in information concerning pain, bowel and bladder management, and pressure sore prevention than older persons with SCI (Hart, Rintala, & Fuhrer, 1996) Several trends have been observed in regard to gender differences Women report an overall higher life satisfaction than men (Dijkers, 1999).



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engineering has initially focused on the development of in vitro culture models for liver cells, in order to characterize cellular responses in distinct environments and to systematically delineate the required extrinsic factors For example, studies have assessed the in vitro morphogenesis of hepatocytes in pure cultures and cocultures [Berthiaume et al, 1996; Bhatia, 1997; Elcin et al, 1998; Haruyama et al, 2000; Powers and Grif th, 1998; Ranucci et al, 2000], as well as hepatocyte metabolic requirements [Balis et al, 1999; Kim et al, 2000; McClelland et al, 2003; Patzer, 2004; Rotem et al, 1994] In addition, in our laboratory we are currently utilizing microfabrication approaches, such as the patterning procedure (See Section 5), to delineate the molecular mechanisms by which broblasts stabilize hepatocyte function, and the dynamics of this process.





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efforts made to minimize and control potential error and bias as well as to maximize both internal and external validity. Randomization is a procedure where research subjects are selected in such a way that they all have an equal chance of being placed in the different experimental and control groups. No bias can occur in deciding which conditions subjects are placed into during the experiment. In conducting experiments using randomization procedures, the experimenter is best able to determine that outcome measures obtained on the dependent variable must be due to the influence of the experimenter-manipulated independent variable and unlikely due to error or other factors. However, several unique challenges are associated with such studies in clinical psychology: It is often impossible or unethical to randomly assign human beings to certain experimental or control conditions. For example, an experimenter interested in the effects of sexual abuse and maternal deprivation on depression could not randomly assign children to an experimental group in which the children would be either sexually abused or deprived of contact with their mothers. It is often impossible or unethical to assign patients to a control condition in which they do not receive treatment. For example, it would be unethical to assign suicidal patients to a control condition for several months without any form of treatment. Furthermore, many patients would refuse to wait for treatment or knowingly accept a placebo treatment. Certain disorders are fairly rare, making it difficult to obtain enough subjects for various experimental and control conditions. For example, an experimenter interested in different treatment approaches for children with trichotillomania (i.e., a disorder that

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Men evidence more problems with pneumonia and other pulmonary/respiratory complications than women (Burns, Putzke, Richards, & Jackson, 2000) Postmenapausal women may experience signi cant deterioration in bone mineral density, contributing to problems with osteoporosis (Weeks, 2001) Descriptive studies imply that persons from ethnic minority groups may face more dif culties in their adjustment Some studies indicate that these persons may have higher levels of distress and lower life satisfaction than Caucasians, and certain secondary complications may be more frequent as well (Elliott & Uswatte, 2000) However, these data are tenuous for several reasons The relations between ethnicity and any outcome variable may be mediated in part by a host of variables including education, access to health care, socioeconomic status, sponsorship, transportation, living arrangements, and trust between consumer and health care provider Without appreciating the sociocultural and community.

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