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require resources external to the database that cannot be completed using T-SQL. In this sense, the CLR is the replacement for the older extended stored procedures. In my opinion, the primary bene t of the CLR is that Microsoft can use it to extend and develop SQL Server. By default, the common language runtime is disabled in SQL Server and must be speci cally enabled using a T-SQL SET command. When enabled, each assembly s scope, or ability to access code outside SQL Server, can be carefully controlled.

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142 Rout M P, Aitchison J D, Suprapto A, Hjertaas K, Zhao Y, Chait B T (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism J Cell Biol 148: 635 652 143 Cronshaw J M, Krutchinsky A N, Zhang W, Chait B T, Matunis M J (2002) Proteomic analysis of the mammalian nuclear pore complex J Cell Biol 158: 915 927 144 Rout M P, Aitchison J D, Magnasco M O, Chait B T (2003) Virtual gating and nuclear transport: the hole picture Trends Cell Biol 13: 622 628 145 Corsi A K, Schekman R (1996) Mechanism of polypeptide translocation into the endoplasmic reticulum J Biol Chem 271: 30299 30302 146 Matlack K E S, Mothes W, Rapoport T A (1998) Protein translocation: tunnel vision Cell 92: 381 390 147 Driessen A J.

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Using the cd command with no arguments automatically returns you to your home directory the directory you were automatically placed in when you logged into the system. This function can be very handy or very confusing.

, Fekkes P, van der Wolk J P (1998) The Sec system Curr Opin Microbiol 1: 216 222 148 Pilon M, Scheckman R (1999) Protein translocation How Hsp70 pulls it off Cell 97: 679 682 149 Agarraberes F A, Dice J F (2001) Protein translocation across membranes Biochim Biophys Acta 1513: 1 24 150 Schnell D J, Hebert D N (2003) Protein translocons: multifunctional mediators of protein translocation across membranes Cell 112: 491 505 151 Eichler J, Irihimovitch V (2003) Move it on over: getting proteins across biological membranes Bioessays 25: 1154 1157 152 Kipping M, Lilie H, Lindenstrauss U, Andreesen J R, Griesinger C, Carlomagno T, Bruser T (2003) Structural studies on a twin-arginine signal sequence FEBS Lett 550: 18 22 153 Hlavacek W S, Faeder J R, Blinov M L, Perelson A S.

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It is for that reason that I reject the submission . . . that, because Maison d Or has been demolished and so will never be repaired, the assessment of damages by reference to the cost of repair is inappropriate. It seems to me that it is not: the cost of repair represents a valid way of arriving at an assessment of the Claimant s loss if, for whatever reason, I conclude that the primary case fails and the costs of demolition and rebuilding are not recoverable. . . . This is unquestionably a case in which the correct measure of loss is reinstatement.

, Goldstein B (2003) The complexity of complexes in signal transduction Biotechnol Bioeng 84: 783 794 154 Aebersold R, Mann M (2003) Mass spectrometry-based proteomics Nature 422: 198 207 155 Blagoev B, Kratchmarova I, Ong S E, Nielsen M, Foster L J, Mann M (2003) A proteomics strategy to elucidate functional protein protein interactions applied to EGF signaling Nat Biotechnol 21: 315 318 156 Ong S E, Foster L J, Mann M (2003) Mass spectrometric-based approaches in quantitative proteomics Methods 29: 124 130 157 Godovac-Zimmermann J, Brown L R (2001) Perspectives for mass spectrometry and functional proteomics Mass Spectrom Rev 20: 1 57 158 Hunter T C, Andon N L, Koller A, Yates I, John R, Haynes P A (2002) The functional proteomics toolbox: methods and applications J Chromatogr B 782: 165 181 159 Foster L.

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J, de Hoog C L, Mann M (2003) Unbiased quantitative proteomics of lipid rafts reveals high speci city for signaling factors Proc Natl Acad Sci USA 100: 5813 5818 160 Resing K A (2002) Analysis of signaling pathways using functional proteomics Ann NY Acad Sci 971: 608 614..

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