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found to inhibit the cytopathogenicity of HIV-1 in CEM-4 cells, including betulinylaminoundecanoic acid (187) with IC50 values of 0.23 and 0.44 mM in CEM and MT-4 cells, respectively. Changing the 3-hydroxy position from 3b (187) to 3a (188) led to a ten-fold decrease in activity (IC50 3.0 and 2.52 mM). The 3-keto compound (189) exhibited intermediate activity. Interestingly, both the 3-deoxy analog (190) and the 3,4-dihydroxy derivative (191) lost activity. Furthermore, the antiviral activities of the 3,4-diketone (192) and 2,3-dehydro (193) derivatives were low. Therefore, chemical modi cation in ring A led to considerable loss of activity77 (Figure 9-10). 9.4.1.2 Modi cation of the C-19 Side Chain Hydrogenation of the isopropylidene double bond (194) reduced the activity of 187 by about ve-fold. The replacement of the isopropylidene by an acetyl (195) or a carboxylic acid (196) led to virtually inactive molecules. However, various



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Each region is equipped with its own automatic international switching centre (ISC) which is connected to the international earth station by a terrestrial link carrying the international channels specific to the region Often, one of these regional ISCs is dedicated as the nation's main ISC and is used for connecting the incoming channels which have not been dedicated by the sending ISC to a particular regional ISC of the receiving country The figure also shows other types of international links, using microwave relays, cables (coaxial or optical fibres, terrestrial or submarine) or even using an alternative satellite link In the example, the traffic between countries A and B is shared between the satellite link and a submarine cable link, in proportions which result from a bilateral agreement and which depend on economic considerations, availability and general management policy.

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The team Feynman found himself in was not actually building the bomb, but looking at methods of getting hold of U-235 in the rst place. In its natural state, uranium mostly consists of the stable U-238 variety, with a very, very small percentage of its radioactive cousin scattered amongst it. Separating out the U-235 was not a trivial task. This was important work, but did not stretch Feynman. As things were going slowly, he managed to get a few weeks off to n256

The results are:

In the routing plan, provision is taken to avoid, as far as possible, double satellite hops Each means (satellite and cable) is also considered as a restoration facility in case of failure of the other As shown in Figure 81, connections between an ISC and the various international transmission means are made through a facility called the ITMC (international transmission maintenance centre) The ITMC forms the interface between the terrestrial links carrying the international channels and the ISC The main equipment and functions usually provided in an ITMC are: line terminating equipment (LTE) for connecting terrestrial cables or transmitter/receiver for connecting radio relay links; multiplexing/demultiplexing; 699.

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One main nding of this chapter is that people hold many incorrect beliefs about nonverbal and verbal cues to deception. This raises the question of where these cues originate. I believe there are three sources, which I will call the moral, exposure, and accusation explanations. The Moral Explanation As I discussed in 2, the stereotypical view is that lying is bad. Charles Bond argues that the belief that liars avoid eye contact ts well with this lying-is-bad stereotype (The Global Deception Team, 2006). If lying is bad, then people should feel ashamed when they lie. People often avert their gaze when they feel ashamed (DePaulo, Lindsay, Malone, Muhlenbruck, Charlton, & Cooper, 2003). Moreover, if lying is bad, then people should feel nervous of getting caught when they lie, resulting in signs of nervousness such as avoiding eye contact, but also in additional nervous cues such as stuttering, talking with a higher pitched voice, and moving about more. This moral reasoning could explain why children as young as ve to six years old already associate gaze aversion and limb movements with deception (Rotenberg & Sullivan, 2003). From a young age, children are taught that it is wrong to lie, and, subsequently, children will associate cues of shame and anxiety with lying. Moral reasoning can also explain why prisoners endorse less than others the belief that liars act nervously. Criminals probably need to lie frequently to succeed in their criminal careers, and therefore probably feel less bad about lying than non-criminals. If they do not feel bad about lying, there is less reason to expect liars to act nervously.

Moreover, the relationship between the instantaneous bond and forward rate volatilities is given by:

You can also use the following array formula to return the sum of the values in the Amount range, where the corresponding value in the Difference range is negative:

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