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Here we emphasize that while core shell micelle formed by a diblock copolymer will be used in the discussion hereafter, the principles are applicable to other morphologies of micellar aggregates and to triblock copolymers as well As with micelles of small-molecule surfactants, the decisive parameter that controls the noncovalent micellar association of BCPs is the hydrophilic hydrophobic balance, ie, the relative importance of the two blocks, which is mainly determined by their relative lengths (BCP composition) and their different solubilities in water (intermolecular interactions with water determined by the chemical structures of the two blocks) In the context of polymer nanocarriers for controlled delivery applications as explained earlier, lightcontrollable BCP micelles are those that can exhibit a structural or morphological change, such as dissociation, disintegration, and swelling, upon interaction with light to allow the release of loaded guest molecules into the aqueous solution.



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25.09.2004 21:11

int standout(void); int wstandout(WINDOW *win);

The function has no arguments. Refer to the w entry later in this appendix for information on the win argument.

To this end, the BCP micelles under illumination should undergo a photoreaction that shifts the hydrophilic hydrophobic balance to make the micelles structurally or morphologically unstable in aqueous solution With azobenzene-containing amphiphilic BCPs, the photoreaction concerned is the reversible trans cis photoisomerization of the chromophore upon UV and visible light illumination, respectively From both the design and synthetic considerations, it is better to link azobenzene moieties onto the hydrophobic polymer In this case, as schematically illustrated in Fig 61, the hydrophobic block, bearing pendant azobenzene moieties in the more stable trans isomer can form the hydrophobic core of the core shell micelle or the membrane of the vesicle.





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On most terminals, standout displays text in reverse video, such as black text on a white background. This function is identical to the following:

decoupled, in the sense that the remote object executes independently of the client and the client does not block during the invocation. This means the pattern is very helpful in event-driven applications that do not rely on a continuous control flow or on return values. Further, it is important that the applications do not rely on successful transmission. during the sending of the invocation to the remote object, or errors that were raised during the execution of the remote invocation, cannot be reported back to the client. The client is unaware of whether the invocation is executed successfully by the remote object. FIRE AND FORGET therefore usually has only best effort semantics. The correctness of the application must not depend on the reliability of a FIRE AND FORGET operation invocation. To cope with this uncertainty, especially in situations in which the client expects some kind of action, clients typically use timeouts to trigger compensating actions.

attron(A_STANDOUT);

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for the encapsulation of hydrophobic and hydrophilic agents, respectively (polymer vesicles can also load hydrophobic agents in the membrane, which is not depicted in Fig. 6.1). Upon illumination with UV light, azobenzene moieties can be converted to the cis isomer. To shift the hydrophilic hydrophobic balance towards the destabilization (dissociation) of the micelles, obviously the cis isomer of azobenzene must be signi cantly more polar than the trans isomer. This is possible by appropriate choice of substitutions on azobenzene. A hint comes from azobenzene without substitution, for which it is known that the elongated trans form has a zero dipole moment, while the bent cis form has a dipole moment of B3 D (Kumar and Neckers, 1989). To obtain a small (near zero) dipole moment for trans-azobenzene linked to the polymer chain backbone, the use of the same substitution groups on the para positions of azobenzene would be most useful since this substitution pattern gives a nearly symmetrical structure for the trans isomer, with no separation of positive and negative charge centers. On the other hand, the cis isomer should have an increased dipole moment owing to the conformational (shape) change. On the contrary, azobenzene structures with strong electron-donor and electron-acceptor groups on the para positions, which would have a higher dipole

In fact, the standout() function may simply be a macro using the attron(A_STANDOUT) function as its definition. standout() is an older Curses function and therefore I recommend avoiding it. Use attron() or attrset() instead.

25.09.2004 21:11

0.01 0 200 400 600 800 Relaxation time (s) 1000 1200

wstandout(output);

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